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dc.contributor.authorStorebø, Michael Langballeen_US
dc.contributor.authorEagan, Tomas Mikalen_US
dc.contributor.authorEide, Geir Egilen_US
dc.contributor.authorGulsvik, Amunden_US
dc.contributor.authorThorsen, Einaren_US
dc.contributor.authorBakke, Per S.en_US
dc.date.accessioned2019-04-08T13:22:37Z
dc.date.available2019-04-08T13:22:37Z
dc.date.issued2016-09-02
dc.identifier.issn2001-8525
dc.identifier.urihttps://hdl.handle.net/1956/19300
dc.description.abstractRationale: Data on the change in diffusion capacity of the lung for carbon monoxide (DLCO) over time are limited. We aimed to examine change in DLCO (ΔDLCO) over a 9-year period and its predictors. Methods: A Norwegian community sample comprising 1,152 subjects aged 18–73 years was examined in 1987 and 1988. Of the 1,109 subjects still alive, 830 (75%) were re-examined in 1996/97. DLCO was measured with the single breath-holding technique. Covariables recorded at baseline included sex, age, height, weight, smoking status, pack years, occupational exposure, educational level, and spirometry. Generalized estimating equations analyses were performed to examine relations between ΔDLCO and the covariables. Results: At baseline, mean [standard deviation (SD)] DLCO was 10.8 (2.4) and 7.8 (1.6) mmol·min−1·kPa−1 in men and women, respectively. Mean (SD) ΔDLCO was −0.24 (1.31) mmol·min−1·kPa−1. ΔDLCO was negatively related to baseline age, DLCO, current smoking, and pack years, and positively related to forced expiratory volume in 1 second (FEV1) and weight. Sex, occupational exposure, and educational level were not related to ΔDLCO. Conclusions: In a community sample, more rapid decline in DLCO during 9 years of observation time was related to higher age, baseline current smoking, more pack years, larger weight, and lower FEV1.en_US
dc.language.isoengeng
dc.publisherTaylor & Franciseng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/eng
dc.subjectdiffusion capacity for carbon monoxideeng
dc.subjectlongitudinal changeeng
dc.subjectoccupational exposureeng
dc.subjectSocioeconomic statuseng
dc.subjectSmokingeng
dc.titleChange in pulmonary diffusion capacity in a general population sample over 9 yearsen_US
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2016 The Author(s)
dc.source.articlenumber31265
dc.identifier.doihttps://doi.org/10.3402/ecrj.v3.31265
dc.identifier.cristin1439216
dc.source.journalEuropean Clinical Respiratory Journal
dc.source.403


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