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dc.contributor.authorChristensen, Monikaen_US
dc.contributor.authorFadnes, Dag Jone Stokkeen_US
dc.contributor.authorRøst, Therese Halvorsenen_US
dc.contributor.authorPedersen, Eva Ringdalen_US
dc.contributor.authorAndersen, John Rogeren_US
dc.contributor.authorVåge, Villyen_US
dc.contributor.authorUlvik, Arveen_US
dc.contributor.authorMidttun, Øivinden_US
dc.contributor.authorUeland, Per Magneen_US
dc.contributor.authorNygård, Ottaren_US
dc.contributor.authorMellgren, Gunnaren_US
dc.PublishedChristensen M, Fadnes DJS, Røst TH, Pedersen ER, Andersen JR, Våge V, Ulvik A, Midttun Ø, Ueland PM, Nygård O, Mellgren G. Inflammatory markers, the tryptophan-kynurenine pathway, and Vitamin B status after bariatric surgery. PLoS ONE. 2018;13(2):e0192169eng
dc.description.abstractObjective: Obesity is associated with increased inflammation and insulin resistance. In conditions with chronic immune activation, low plasma vitamin B6-levels are described, as well as an increased kynurenine:tryptophan-ratio (KTR). We investigated circulating tryptophan, kynurenine and its metabolites, neopterin, B-vitamins, CRP, and HbA1c in individuals with obesity before and after bariatric surgery. Methods: This longitudinal study included 37 patients with severe obesity, scheduled for bariatric surgery. Blood samples were taken at inclusion and at three months and one year postoperatively. Results: We observed significant positive correlations between HbA1c and both 3-hydroxy-kynurenine and 3-hydroxyanthranilic acid at inclusion. After surgery, fasting glucose, HbA1C and triglycerides decreased, whereas HDL-cholesterol increased. Tryptophan, kynurenine and its metabolites, except for anthranilic acid, decreased during weight loss. The KTR and CRP decreased while vitamin B6 increased during the year following operation, indicating reduced inflammation (all p<0.05). Conclusions: In patients with obesity subjected to bariatric surgery, levels of 3-hydroxykynurenine and 3-hydroxyanthranilic acid seemed to be positively correlated to impaired glucose tolerance. One year following surgery, plasma levels of the kynurenine metabolites were substantially decreased, along with a metabolic improvement. The relation of circulating kynurenine pathway metabolites with biomarkers of metabolic impairment in patients with obesity needs further evaluation.en_US
dc.rightsAttribution CC BYeng
dc.titleInflammatory markers, the tryptophan-kynurenine pathway, and Vitamin B status after bariatric surgeryen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2018 The Author(s)
dc.source.journalPLoS ONE

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