Browsing Master theses by Issue Date
Now showing items 1-18 of 18
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Making in vivo models viable again: Synthetic lethality between DNA repair factors Xlf and Paxx is rescued by inactivation of Trp53
(Master thesis, 2019-06-28)Non-Homologous End-Joining (NHEJ) is the major DNA repair pathway that senses, processes and ligates DNA double strand breaks (DSBs) in higher eukaryotes, functionally throughout the cell cycle. The NHEJ involves four core ... -
The role of pyruvate dehydrogenase kinases (PDKs) in rewiring of cell metabolism under energy stress
(Master thesis, 2019-06-28)Irregularities in cellular energy metabolism have been linked to many human diseases, including metabolic disorders, mitochondrial diseases, cancer, and neurodegeneration. In order to survive and function properly, an ... -
A novel 3D PDAC model system developed with the use of decellularized matrix scaffolds
(Master thesis, 2019-06-28) -
Exploring the IBS Brain: Resting State Functional Connectivity and Machine Learning
(Master thesis, 2019-06-28) -
In vitro study of a selective PI3K inhibitor on brain metastases
(Master thesis, 2020-06-17) -
CEL in pancreatic disease: Do alcohol and smoking have an effect on the CEL-HYB1 protein?
(Master thesis, 2020-06-23) -
Structure-based design of pantothenate kinase inhibitors as lead structures for new antibiotics
(Master thesis, 2020-06-23) -
TOWARDS DEFINING THE ENDOMEMBRANE COMPARTMENTS OPERATING IN CELLULAR EXIT OF CORONVIRUSES
(Master thesis, 2021-06-01) -
The Search for Antibiotic Leads: Targeting Pantothenate Kinase in Pseudomonas aeruginosa
(Master thesis, 2021-06-01) -
Improvement of a 3D model system for the evaluation and treatment of pancreatic ductal adenocarcinoma
(Master thesis, 2021-06-01) -
Development and Characterization of an ex vivo Organotypic Non-Small Cell Lung Cancer Model to Study the Effect of Elevated Oxygen Treatment
(Master thesis, 2021-06-01)Lung cancer is a leading cause of cancer-related morbidity and mortality worldwide, and also the cancer-form responsible for most cancer related deaths in Norway. Non-small cell lung cancer (NSCLC) accounts for approximately ... -
Development of 3D in vitro Interaction Models for the Evaluation and Treatment of Brain Metastases
(Master thesis, 2021-06-01) -
The Role of apoptosis in suicide gene therapy of glioblastoma
(Master thesis, 2021-12-01) -
Effect of miR-582-5p modulated cancer-associated fibroblasts on vulvar cancer cells
(Master thesis, 2022-06-01) -
Investigation of the Role of BCR/ABL1 in Neutrophil Extracellular Trap (NET) Formation in Chronic Myeloid Leukemia (CML)
(Master thesis, 2022-06-01)Neutrophil extracellular traps (NETs) represent a rather newly discovered antimicrobial mechanism first described by Brinkmann and co-workers in 2004. NETs are extracellular structures composed of decondensed chromatin ... -
Cellular clearance and protein binding partners of pathogenic CEL-HYB
(Master thesis, 2022-06-01)The CEL gene encodes the digestive enzyme carboxyl ester lipase, which is mainly expressed in the acinar cells of the pancreas. In 2015, our research group discovered a CEL hybrid gene, named CEL-HYB, resulting from ... -
CHARACTERIZATION OF IMMUNE CELL SUBSETS IN A MODEL DISEASE FOR ENDOCRINE AUTOIMMUNITY BY MASS AND FLOW CYTOMETRY
(Master thesis, 2022-06-01)The autoimmune polyendocrine syndrome type 1 (APS1) is a complex and rare monogenic form of autoimmunity caused by pathogenic variants of the autoimmune regulator (AIRE) gene; a transcription factor primarily expressed in ... -
Pharmacological targeting of the Treg/Th17 axis using in vitro cell cultures derived from patients with autoimmune Addison's disease
(Master thesis, 2022-06-01)Autoimmune Addison’s disease (AAD) is a rare endocrine disorder characterized by an immune-mediated attack towards the cells of the adrenal cortex. The major self-antigen, targeted by autoantibodies and self-reactive T ...