Browsing Master theses by Title
Now showing items 26-33 of 33
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Role of mechanotransduction in pancreatic endocrine cell fate acquisition in SC-islets
(Master thesis, 2024-06-03) -
The role of pyruvate dehydrogenase kinases (PDKs) in rewiring of cell metabolism under energy stress
(Master thesis, 2019-06-28)Irregularities in cellular energy metabolism have been linked to many human diseases, including metabolic disorders, mitochondrial diseases, cancer, and neurodegeneration. In order to survive and function properly, an ... -
Structure-based design of pantothenate kinase inhibitors as lead structures for new antibiotics
(Master thesis, 2020-06-23) -
The CEL VNTR in pancreatic disease: Effects of cysteine residues in pathogenic carboxyl ester lipase variants
(Master thesis, 2023-06-01)Carboxyl ester lipase (CEL) is a digestive enzyme mainly expressed in the acinar cells of the pancreas. CEL hydrolyses dietary fat, cholesteryl esters and fat-soluble vitamins. The protein is structurally divided into two ... -
The Role of apoptosis in suicide gene therapy of glioblastoma
(Master thesis, 2021-12-01) -
The Search for Antibiotic Leads: Targeting Pantothenate Kinase in Pseudomonas aeruginosa
(Master thesis, 2021-06-01) -
TOWARDS DEFINING THE ENDOMEMBRANE COMPARTMENTS OPERATING IN CELLULAR EXIT OF CORONVIRUSES
(Master thesis, 2021-06-01) -
Using iPSC-derived cortical organoids to study disease mechanisms of POLG-disease and explore new therapeutic strategies
(Master thesis, 2023-07-03)POLG-related diseases are a set of severe mitochondrial myopathies caused by a mutation in the POLG gene. The POLG gene encodes for the catalytic subunit of the mitochondrial DNA (mtDNA) polymerase gamma (Pol-γ). Pol-γ is ...