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dc.contributor.authorTomescu-Baciu, Alinaen_US
dc.contributor.authorVartdal, Frodeen_US
dc.contributor.authorHolmøy, Trygveen_US
dc.contributor.authorVedeler, Christian A.en_US
dc.contributor.authorLossius, Peter Andreas Volden_US
dc.PublishedTomescu-Baciu A, Vartdal F, Holmøy T, Vedeler CA, Lossius PAV. G1m1 predominance of intrathecal virus-specific antibodies in multiple sclerosis. Annals of clinical and translational neurology. 2018;5(10):1303-1309eng
dc.description.abstractWe have previously shown that plasmablasts of the G1m1 allotype of IgG1 are selectively enriched in the cerebrospinal fluid of G1m1/G1m3 heterozygous patients with multiple sclerosis, whereas both allotypes are equally used in neuroborreliosis. Here, we demonstrate a strong preference for the G1m1 allotype in the intrathecal humoral immune responses against measles, rubella, and varicella zoster virus in G1m1/G1m3 heterozygous multiple sclerosis patients. Conversely, intrathecally synthesized varicella zoster virus‐specific IgG1 in varicella zoster virus meningoencephalitis comprised both allotypes. This implies that G1m1 B cells are selected to the central nervous system of multiple sclerosis patients regardless of specificity and suggests that an antigen‐independent mechanism could drive the intrathecal humoral immune response.en_US
dc.publisherWiley Open Accesseng
dc.rightsCC BY-NC-ND 4.0eng
dc.titleG1m1 predominance of intrathecal virus-specific antibodies in multiple sclerosisen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright © 1999-2019 John Wiley & Sons, Inc.
dc.source.journalAnnals of clinical and translational neurology
dc.relation.projectHelse Sør-Øst RHF: 2016079

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