dc.contributor.author | Tomescu-Baciu, Alina | en_US |
dc.contributor.author | Vartdal, Frode | en_US |
dc.contributor.author | Holmøy, Trygve | en_US |
dc.contributor.author | Vedeler, Christian A. | en_US |
dc.contributor.author | Lossius, Peter Andreas Vold | en_US |
dc.date.accessioned | 2019-05-23T16:18:49Z | |
dc.date.available | 2019-05-23T16:18:49Z | |
dc.date.issued | 2018-09-17 | |
dc.Published | Tomescu-Baciu A, Vartdal F, Holmøy T, Vedeler CA, Lossius PAV. G1m1 predominance of intrathecal virus-specific antibodies in multiple sclerosis. Annals of clinical and translational neurology. 2018;5(10):1303-1309 | eng |
dc.identifier.issn | 2328-9503 | |
dc.identifier.uri | https://hdl.handle.net/1956/19717 | |
dc.description.abstract | We have previously shown that plasmablasts of the G1m1 allotype of IgG1 are selectively enriched in the cerebrospinal fluid of G1m1/G1m3 heterozygous patients with multiple sclerosis, whereas both allotypes are equally used in neuroborreliosis. Here, we demonstrate a strong preference for the G1m1 allotype in the intrathecal humoral immune responses against measles, rubella, and varicella zoster virus in G1m1/G1m3 heterozygous multiple sclerosis patients. Conversely, intrathecally synthesized varicella zoster virus‐specific IgG1 in varicella zoster virus meningoencephalitis comprised both allotypes. This implies that G1m1 B cells are selected to the central nervous system of multiple sclerosis patients regardless of specificity and suggests that an antigen‐independent mechanism could drive the intrathecal humoral immune response. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Wiley Open Access | eng |
dc.rights | CC BY-NC-ND 4.0 | eng |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | eng |
dc.title | G1m1 predominance of intrathecal virus-specific antibodies in multiple sclerosis | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2019-01-31T18:06:49Z | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright © 1999-2019 John Wiley & Sons, Inc. | |
dc.identifier.doi | https://doi.org/10.1002/acn3.642 | |
dc.identifier.cristin | 1618466 | |
dc.source.journal | Annals of clinical and translational neurology | |
dc.relation.project | Helse Sør-Øst RHF: 2016079 | |