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dc.contributor.authorWitoelar, Areeen_US
dc.contributor.authorRongve, Arviden_US
dc.contributor.authorAlmdahl, Ina Selsethen_US
dc.contributor.authorUlstein, Ingunen_US
dc.contributor.authorEngvig, Andreasen_US
dc.contributor.authorWhite, Linda Rosemaryen_US
dc.contributor.authorSelbæk, Geiren_US
dc.contributor.authorStordal, Eysteinen_US
dc.contributor.authorAndersen, Fredriken_US
dc.contributor.authorBrækhus, Anneen_US
dc.contributor.authorSaltvedt, Ingvilden_US
dc.contributor.authorEngedal, Knuten_US
dc.contributor.authorHughes, Timothyen_US
dc.contributor.authorBergh, Sverreen_US
dc.contributor.authorBråthen, Geiren_US
dc.contributor.authorBogdanovic, Nenaden_US
dc.contributor.authorBettella, Francescoen_US
dc.contributor.authorWang, Yunpengen_US
dc.contributor.authorAthanasiu, Laviniaen_US
dc.contributor.authorBahrami, Shahramen_US
dc.contributor.authorLe Hellard, Stephanieen_US
dc.contributor.authorGiddaluru, Sudheeren_US
dc.contributor.authorDale, Anders Men_US
dc.contributor.authorSando, Sigrid Botneen_US
dc.contributor.authorSteinberg, Stacyen_US
dc.contributor.authorStefansson, Hreinnen_US
dc.contributor.authorSnaedal, Jonen_US
dc.contributor.authorDesikan, Rahul Sen_US
dc.contributor.authorStefansson, Karien_US
dc.contributor.authorAarsland, Dagen_US
dc.contributor.authorDjurovic, Srdjanen_US
dc.contributor.authorFladby, Tormoden_US
dc.contributor.authorAndreassen, Ole Andreasen_US
dc.PublishedWitoelar AW, Rongve A, Almdahl I, Ulstein I, Engvig A, White LR, Selbæk GS, Stordal E, Andersen F, Brækhus A, Saltvedt IS, Engedal K, Hughes T, Bergh S, Bråthen GBr, Bogdanovic B, Bettella F, Wang Y, Athanasiu L, Bahrami S, Le Hellard S, Giddaluru S, Dale AM, Sando SB, Steinberg S, Stefansson H, Snaedal J, Desikan RS, Stefansson K, Aarsland D, Djurovic S, Fladby T, Andreassen OA. Meta-analysis of Alzheimer’s disease on 9,751 samples from Norway and IGAP study identifies four risk loci. Scientific Reports. 2018eng
dc.description.abstractA large fraction of genetic risk factors for Alzheimer’s Disease (AD) is still not identified, limiting the understanding of AD pathology and study of therapeutic targets. We conducted a genome-wide association study (GWAS) of AD cases and controls of European descent from the multi-center DemGene network across Norway and two independent European cohorts. In a two-stage process, we first performed a meta-analysis using GWAS results from 2,893 AD cases and 6,858 cognitively normal controls from Norway and 25,580 cases and 48,466 controls from the International Genomics of Alzheimer’s Project (IGAP), denoted the discovery sample. Second, we selected the top hits (p < 1 × 10−6) from the discovery analysis for replication in an Icelandic cohort consisting of 5,341 cases and 110,008 controls. We identified a novel genomic region with genome-wide significant association with AD on chromosome 4 (combined analysis OR = 1.07, p = 2.48 x 10-8). This finding implicated HS3ST1, a gene expressed throughout the brain particularly in the cerebellar cortex. In addition, we identified IGHV1-68 in the discovery sample, previously not associated with AD. We also associated USP6NL/ECHDC3 and BZRAP1-AS1 to AD, confirming findings from a follow-up transethnic study. These new gene loci provide further evidence for AD as a polygenic disorder, and suggest new mechanistic pathways that warrant further investigation.en_US
dc.publisherSpringer Natureeng
dc.rightsAttribution CC BYeng
dc.subjectAlzheimer's diseaseeng
dc.subjectDisease geneticseng
dc.subjectGenome-wide association studieseng
dc.subjectPredictive markerseng
dc.titleMeta-analysis of Alzheimer’s disease on 9,751 samples from Norway and IGAP study identifies four risk locien_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright The Author(s) 2018
dc.source.journalScientific Reports
dc.relation.projectNorges forskningsråd: 251134

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