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dc.contributor.authorSrinivasan, Saurabhen_US
dc.contributor.authorBettella, Francescoen_US
dc.contributor.authorFrei, Oleksandren_US
dc.contributor.authorHill, W. Daviden_US
dc.contributor.authorWang, Yunpengen_US
dc.contributor.authorWitoelar, Areeen_US
dc.contributor.authorSchork, Andrew J.en_US
dc.contributor.authorThompson, Wesley Kurten_US
dc.contributor.authorDavies, Gailen_US
dc.contributor.authorDesikan, Rahul S.en_US
dc.contributor.authorDeary, Ian J.en_US
dc.contributor.authorMelle, Ingriden_US
dc.contributor.authorUeland, Torillen_US
dc.contributor.authorDale, Andersen_US
dc.contributor.authorDjurovic, Srdjanen_US
dc.contributor.authorSmeland, Olav Bjerkehagenen_US
dc.contributor.authorAndreassen, Ole Andreasen_US
dc.PublishedSrinivasan S, Bettella F, Frei O, Hill WD, Wang Y, Witoelar AW, Schork AJ, Thompson WK, Davies G, Desikan RS, Deary IJ, Melle I, Ueland T, Dale A, Djurovic S, Smeland OB, Andreassen OA. Enrichment of genetic markers of recent human evolution in educational and cognitive traits. Scientific Reports. 2018;8:12585:1-9eng
dc.description.abstractHigher cognitive functions are regarded as one of the main distinctive traits of humans. Evidence for the cognitive evolution of human beings is mainly based on fossil records of an expanding cranium and an increasing complexity of material culture artefacts. However, the molecular genetic factors involved in the evolution are still relatively unexplored. Here, we investigated whether genomic regions that underwent positive selection in humans after divergence from Neanderthals are enriched for genetic association with phenotypes related to cognitive functions. We used genome wide association data from a study of college completion (N = 111,114), one of educational attainment (N = 293,623) and two different studies of general cognitive ability (N = 269,867 and 53,949). We found nominally significant polygenic enrichment of associations with college completion (p = 0.025), educational attainment (p = 0.043) and general cognitive ability (p = 0.015 and 0.025, respectively), suggesting that variants influencing these phenotypes are more prevalent in evolutionarily salient regions. The enrichment remained significant after controlling for other known genetic enrichment factors, and for affiliation to genes highly expressed in the brain. These findings support the notion that phenotypes related to higher order cognitive skills typical of humans have a recent genetic component that originated after the separation of the human and Neanderthal lineages.en_US
dc.publisherSpringer Natureeng
dc.rightsAttribution CC BYeng
dc.titleEnrichment of genetic markers of recent human evolution in educational and cognitive traitsen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright The Author(s) 2018
dc.source.journalScientific Reports
dc.relation.projectNorges forskningsråd: 251134

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