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dc.contributor.authorLudvigsen, Stianen_US
dc.contributor.authorMancusi, Costantinoen_US
dc.contributor.authorKildal, Simonen_US
dc.contributor.authorde Simone, Giovannien_US
dc.contributor.authorGerdts, Evaen_US
dc.contributor.authorYtrehus, Kirstien_US
dc.PublishedLudvigsen S, Mancusi C, Kildal S, de Simone G, Gerdts E, Ytrehus k. Cardiac adaptation to hypertension in adult female Dahl salt-sensitive rats is dependent on ovarian function, but loss of ovarian function does not predict early maladaptation. Physiological Reports. 2018;6(3):e13593eng
dc.description.abstractAim of study was to examine experimentally the adult female hypertensive heart in order to determine the role of ovary function in the response of the heart to salt‐dependent hypertension. Dahl salt‐sensitive rats, age 12 weeks, with/without ovariectomy were fed a standard (0.3% NaCl) or high‐salt diet (8%) for 16 weeks. Mean arterial blood pressure monitored noninvasively in conscious state increased significantly by high salt. Echocardiography was performed at baseline and endpoint. Heart function and molecular changes were evaluated at endpoint by left ventricle catheterization, by sirius red staining for collagen and by gene expression using quantitative RT‐PCR for selected genes. At endpoint, significant concentric hypertrophy was present with high salt. Increase in relative wall thickening with high salt compared to normal diet was more pronounced with intact ovaries (0.33 ± 0.02 and 0.57 ± 0.04 vs. 0.29 ± 0.00 and 0.46 ± 0.03) as was the reduction in midwall fractional shortening (20 ± 0.6 and 14 ± 2 vs. 19 ± 0.9 and 18 ± 1). Ovariectomy increased stroke volume and decreased the ratio of mitral peak velocity of early filling (E) to early diastolic mitral annular velocity (E′) (E/E' ratio) when compared to hearts from intact rats. High salt increased expression of collagen I and III genes and perivascular collagen in the heart slightly, but % interstitial collagen by sirius red staining remained unchanged in intact rats and decreased significantly by ovariectomy. Added volume load but not deterioration of function or structure characterized the nonfailing hypertensive heart of salt‐sensitive females ovariectomized at mature age when compared to corresponding intact females.en_US
dc.publisherWiley Open Accesseng
dc.rightsAttribution CC BYeng
dc.subjectGene expressioneng
dc.subjectheart hypertrophyeng
dc.subjectheart remodelingeng
dc.titleCardiac adaptation to hypertension in adult female Dahl salt-sensitive rats is dependent on ovarian function, but loss of ovarian function does not predict early maladaptationen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2018 The Authors
dc.source.journalPhysiological Reports

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