dc.contributor.author | Reikvam, Håkon | en_US |
dc.contributor.author | Skavland, Jørn | en_US |
dc.contributor.author | Gullaksen, Stein-Erik | en_US |
dc.contributor.author | Hovland, Randi | en_US |
dc.contributor.author | Gedde-Dahl, Tobias | en_US |
dc.contributor.author | Bruserud, Øystein | en_US |
dc.contributor.author | Gjertsen, Bjørn Tore | en_US |
dc.date.accessioned | 2019-05-29T16:09:33Z | |
dc.date.available | 2019-05-29T16:09:33Z | |
dc.date.issued | 2018-09-23 | |
dc.Published | Reikvam H, Skavland J, Gullaksen S, Hovland R, Gedde-Dahl T, Bruserud Ø, Gjertsen BT. Chronic Myeloid Leukemia Relapsing 25 Years after Allogenic Stem Cell Transplantation. Case reports in hematology. 2018;2045985 | eng |
dc.identifier.issn | 2090-6560 | |
dc.identifier.issn | 2090-6579 | |
dc.identifier.uri | https://hdl.handle.net/1956/19826 | |
dc.description.abstract | Chronic myeloid leukemia (CML) is a myeloproliferative disorder in which neoplastic cells exhibit the Philadelphia chromosome and the related oncoprotein BCR-ABL1. Allogeneic stem cell transplantation (allo-SCT) was considered the first-line treatment for CML, before the introduction of tyrosine kinase inhibitors (TKIs). However, patients are at risk for relapse years after transplantation. We present a patient who relapsed 25 years after allo-SCT for chronic phase CML. Polymerase chain reaction (PCR) detected gradually evaluated levels of BCR-ABL1 transcripts, eventually leading to the diagnosis of relapsed disease. Additional mutational analyses did not reveal mutations in the BCR-ABL1 gene, or other cooperating mutations. The patient was successfully treated with imatinib 400 mg daily, leading to new molecular remission. The case presentation emphasizes the need for long-term follow-up of such patients and the potential benefit of initiating TKI treatment with early signs of relapse. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Hindawi | eng |
dc.rights | Attribution CC BY | eng |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | eng |
dc.title | Chronic Myeloid Leukemia Relapsing 25 Years after Allogenic Stem Cell Transplantation | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2019-03-21T15:07:05Z | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2018 The Authors | |
dc.identifier.doi | https://doi.org/10.1155/2018/2045985 | |
dc.identifier.cristin | 1686558 | |
dc.source.journal | Case reports in hematology | |