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dc.contributor.authorThunemann, Martinen_US
dc.contributor.authorLu, Yichenen_US
dc.contributor.authorLiu, Xinen_US
dc.contributor.authorKılıç, Kıvılcımen_US
dc.contributor.authorDesjardins, Michèleen_US
dc.contributor.authorVandenberghe, Matthieuen_US
dc.contributor.authorSadegh, Sanazen_US
dc.contributor.authorSaisan, Payam A.en_US
dc.contributor.authorCheng, Qunen_US
dc.contributor.authorWeldy, Kimberly L.en_US
dc.contributor.authorLyu, Hongmingen_US
dc.contributor.authorDjurovic, Srdjanen_US
dc.contributor.authorAndreassen, Ole Andreasen_US
dc.contributor.authorDale, Andersen_US
dc.contributor.authorDevor, Annaen_US
dc.contributor.authorKuzum, Duyguen_US
dc.date.accessioned2019-05-31T12:09:28Z
dc.date.available2019-05-31T12:09:28Z
dc.date.issued2018-05-23
dc.PublishedThunemann M, Lu, Liu X, Kılıç K, Desjardins M, Vandenberghe M, Sadegh, Saisan PA, Cheng Q, Weldy KL, Lyu, Djurovic S, Andreassen OA, Dale A, Devor A, Kuzum. Deep 2-photon imaging and artifact-free optogenetics through transparent graphene microelectrode arrays. Nature Communications. 2018;9:2035eng
dc.identifier.issn2041-1723
dc.identifier.urihttps://hdl.handle.net/1956/19831
dc.description.abstractRecent advances in optical technologies such as multi-photon microscopy and optogenetics have revolutionized our ability to record and manipulate neuronal activity. Combining optical techniques with electrical recordings is of critical importance to connect the large body of neuroscience knowledge obtained from animal models to human studies mainly relying on electrophysiological recordings of brain-scale activity. However, integration of optical modalities with electrical recordings is challenging due to generation of light-induced artifacts. Here we report a transparent graphene microelectrode technology that eliminates light-induced artifacts to enable crosstalk-free integration of 2-photon microscopy, optogenetic stimulation, and cortical recordings in the same in vivo experiment. We achieve fabrication of crack- and residue-free graphene electrode surfaces yielding high optical transmittance for 2-photon imaging down to ~ 1 mm below the cortical surface. Transparent graphene microelectrode technology offers a practical pathway to investigate neuronal activity over multiple spatial scales extending from single neurons to large neuronal populations.en_US
dc.language.isoengeng
dc.publisherSpringer Natureeng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0eng
dc.titleDeep 2-photon imaging and artifact-free optogenetics through transparent graphene microelectrode arraysen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2019-01-30T13:29:33Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2018 The Author(s)
dc.identifier.doihttps://doi.org/10.1038/s41467-018-04457-5
dc.identifier.cristin1593814
dc.source.journalNature Communications
dc.relation.projectHelse Sør-Øst RHF: 2018094


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