Show simple item record

dc.contributor.authorStørdal, Ketilen_US
dc.contributor.authorMcArdle, Harry J.en_US
dc.contributor.authorHayes, Helenen_US
dc.contributor.authorTapia, Germanen_US
dc.contributor.authorViken, Marte Ken_US
dc.contributor.authorLund-Blix, Nicolai Andreen_US
dc.contributor.authorHaugen, Margarethaen_US
dc.contributor.authorJoner, Geiren_US
dc.contributor.authorSkrivarhaug, Torilden_US
dc.contributor.authorMårild, Karl Staffanen_US
dc.contributor.authorNjølstad, Pål Rasmusen_US
dc.contributor.authorEggesbø, Merete Åseen_US
dc.contributor.authorMandal, Siddharthaen_US
dc.contributor.authorPage, Christianen_US
dc.contributor.authorLondon, Stephanie J.en_US
dc.contributor.authorLie, Benedicte Alexandraen_US
dc.contributor.authorStene, Lars Christian Mørchen_US
dc.PublishedStørdal K, McArdle, Hayes, Tapia G, Viken MK, Lund-Blix NA, Haugen M, Joner GJ, Skrivarhaug T, Mårild K, Njølstad PR, Eggesbø MÅ, Mandal S, Page C, London SJ, Lie BA, Stene LC. Prenatal iron exposure and childhood type 1 diabetes. Scientific Reports. 2018;8:9067eng
dc.description.abstractIron overload due to environmental or genetic causes have been associated diabetes. We hypothesized that prenatal iron exposure is associated with higher risk of childhood type 1 diabetes. In the Norwegian Mother and Child cohort study (n = 94,209 pregnancies, n = 373 developed type 1 diabetes) the incidence of type 1 diabetes was higher in children exposed to maternal iron supplementation than unexposed (36.8/100,000/year compared to 28.6/100,000/year, adjusted hazard ratio 1.33, 95%CI: 1.06–1.67). Cord plasma biomarkers of high iron status were non-significantly associated with higher risk of type 1 diabetes (ferritin OR = 1.05 [95%CI: 0.99–1.13] per 50 mg/L increase; soluble transferrin receptor: OR = 0.91 [95%CI: 0.81–1.01] per 0.5 mg/L increase). Maternal but not fetal HFE genotypes causing high/intermediate iron stores were associated with offspring diabetes (odds ratio: 1.45, 95%CI: 1.04, 2.02). Maternal anaemia or non-iron dietary supplements did not significantly predict type 1 diabetes. Perinatal iron exposures were not associated with cord blood DNA genome-wide methylation, but fetal HFE genotype was associated with differential fetal methylation near HFE. Maternal cytokines in mid-pregnancy of the pro-inflammatory M1 pathway differed by maternal iron supplements and HFE genotype. Our results suggest that exposure to iron during pregnancy may be a risk factor for type 1 diabetes in the offspring.en_US
dc.publisherSpringer Natureeng
dc.rightsAttribution CC BYeng
dc.titlePrenatal iron exposure and childhood type 1 diabetesen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2018 The Author(s)
dc.source.journalScientific Reports

Files in this item


This item appears in the following Collection(s)

Show simple item record

Attribution CC BY
Except where otherwise noted, this item's license is described as Attribution CC BY