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dc.contributor.authorBerg, Akiah Ottesenen_US
dc.contributor.authorJørgensen, Kjetil Nordbøen_US
dc.contributor.authorNerhus, Marien_US
dc.contributor.authorAthanasiu, Laviniaen_US
dc.contributor.authorPopejoy, Aliceen_US
dc.contributor.authorBettella, Francescoen_US
dc.contributor.authorNorbom, Linn Christin Bonaventureen_US
dc.contributor.authorGurholt, Tiril Pedersenen_US
dc.contributor.authorDahl, Sandra Rinneen_US
dc.contributor.authorAndreassen, Ole Andreasen_US
dc.contributor.authorDjurovic, Srdjanen_US
dc.contributor.authorAgartz, Ingriden_US
dc.contributor.authorMelle, Ingriden_US
dc.date.accessioned2019-06-19T10:46:02Z
dc.date.available2019-06-19T10:46:02Z
dc.date.issued2018-08-24
dc.PublishedBerg AO, Jørgensen Kn, Nerhus M, Athanasiu L, Popejoy A, Bettella F, Norbom L, Gurholt TP, Dahl S, Andreassen OA, Djurovic S, Agartz I, Melle I. Vitamin D levels, brain volume, and genetic architecture in patients with psychosis. PLoS ONE. 2018;13(8):e0200250eng
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/1956/20235
dc.description.abstractBackground: Lower vitamin D levels are found in people with schizophrenia and depressive disorders, and also associated with neuroimaging abnormalities such as reduced brain volume in both animals and humans. Reduced whole brain and increased ventricular volume are also systematically reported in schizophrenia. Even though vitamin D deficiency has been proposed as a risk mechanism for schizophrenia there exist no studies to date of the association between vitamin D levels and brain volume in this population. Therefore, we investigated the relationship between vitamin D levels and brain phenotypes in psychotic disorders, and assessed possible interactions with genetic variants in vitamin D receptor (VDR) and other genetic variants that play a role in vitamin D levels in the body. Methods: Our sample consisted of 83 psychosis patients and 101 healthy controls. We measured vitamin D levels as serum 25-hydroxyvitamin D. All participants were genotyped and neuroimaging conducted by structural magnetic resonance imaging. Results: Vitamin D levels were significantly positively associated with peripheral grey matter volume in patients (β 860.6; 95% confidence interval (CI) 333.4–1466, p < .003). A significant interaction effect of BSML marker (rs1544410) was observed to mediate the association between patient status and both white matter volume (β 23603.3; 95% CI 2732.8–48708.6, p < .05) and whole brain volume (β 46670.6, 95% CI 8817.8–93888.3, p < .04). Vitamin D did not predict ventricular volume, which rather was associated with patient status (β 4423.3, 95% CI 1583.2–7267.8p < .002) and CYP24A1 marker (rs6013897) (β 2491.5, 95% CI 269.7–4978.5, p < .04). Conclusions: This is the first study of the association between vitamin D levels and brain volume in patients with psychotic disorders that takes into account possible interaction with genetic polymorphisms. The present findings warrant replication in independent samples.en_US
dc.language.isoengeng
dc.publisherPLOSeng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0eng
dc.titleVitamin D levels, brain volume, and genetic architecture in patients with psychosisen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2019-01-30T10:29:34Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2018 The Author(s)
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0200250
dc.identifier.cristin1610754
dc.source.journalPLoS ONE


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