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dc.contributor.authorSane Schepisi, Monicaen_US
dc.contributor.authorNavarra, Assuntaen_US
dc.contributor.authorAltet Gómez, Maria de las Nievesen_US
dc.contributor.authorDudnyk, Andriien_US
dc.contributor.authorDyrhol-Riise, Anne Maen_US
dc.contributor.authorEsteban, Jaimeen_US
dc.contributor.authorGiorgetti, Pier Francescoen_US
dc.contributor.authorGualano, Ginaen_US
dc.contributor.authorGuglielmetti, Lorenzoen_US
dc.contributor.authorHeyckendorf, Janen_US
dc.contributor.authorKaluzhenina, Annaen_US
dc.contributor.authorLange, Beriten_US
dc.contributor.authorLange, Christophen_US
dc.contributor.authorManika, Katerinaen_US
dc.contributor.authorMiah, Jalalen_US
dc.contributor.authorNanovic, Zoricaen_US
dc.contributor.authorPontali, Emanueleen_US
dc.contributor.authorPrego, Monica Riosen_US
dc.contributor.authorSolovič, Ivanen_US
dc.contributor.authorTiberi, Simonen_US
dc.contributor.authorPalmieri, Fabrizioen_US
dc.contributor.authorGirardi, Enricoen_US
dc.PublishedSane Schepisi, Navarra, Altet Gómez, Dudnyk, Dyrhol-Riise AM, Esteban J, Giorgetti, Gualano, Guglielmetti, Heyckendorf, Kaluzhenina, Lange, Lange C, Manika, Miah, Nanovic, Pontali, Prego, Solovič, Tiberi, Palmieri, Girardi. Burden and characteristics of the comorbidity tuberculosis - diabetes in Europe: TBnet prevalence survey and case-control study. Open Forum Infectious Diseases. 2019;6(1):1-8.eng
dc.description.abstractBackground: The growing burden of diabetes mellitus (DM) is posing a threat to global tuberculosis (TB) control. DM triples the risk of developing TB, modifies the presenting features of pulmonary TB, and worsens TB treatment outcomes. We aimed to analyze the prevalence of DM among TB patients and to describe the characteristics and clinical presentation of TB-DM patients in Europe. Methods: We performed a cross-sectional survey on the prevalence of DM among consecutively diagnosed adult TB patients in 11 European TB referral centers located in France, Germany, Greece, Italy, Russia, Slovakia, Spain, and the United Kingdom over the period 2007–2015. We also selected DM-TB cases and TB only controls with a 1:3 ratio to perform a case-control analysis, including patients selected from the countries mentioned above plus Norway and Ukraine. Results: Among 3143 TB enrolled patients, DM prevalence overall was 10.7% and ranged from 4.4% in Greece to 28.5% in the United Kingdom. Patients’ median ages ranged from 36 to 49 years, and all centers had >60% males; the proportion of foreign-born patients varied widely across sites. In the case-control study, DM was independently associated with older age and, among older patients, with being foreign-born. Among patients with pulmonary involvement, cavities on chest imaging were more frequently observed among those with DM. Conclusions: Diabetes mellitus represents a challenge for TB control in Europe, especially in foreign-born and in elderly patients. Specific screening strategies should be evaluated.en_US
dc.publisherOxford University Presseng
dc.rightsAttribution CC BY 4.0eng
dc.subjectDiabetes mellituseng
dc.titleBurden and characteristics of the comorbidity tuberculosis - diabetes in Europe : TBnet prevalence survey and case-control studyen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2018 The Author(s).
dc.source.journalOpen Forum Infectious Diseases

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