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dc.contributor.authorMacpherson, Magnhild Eideen_US
dc.contributor.authorHalvorsen, Benteen_US
dc.contributor.authorYndestad, Arneen_US
dc.contributor.authorUeland, Thoren_US
dc.contributor.authorMollnes, Tom Eiriken_US
dc.contributor.authorBerge, Rolf Kristianen_US
dc.contributor.authorRashidi, Azitaen_US
dc.contributor.authorOtterdal, Karien_US
dc.contributor.authorGregersen, Idaen_US
dc.contributor.authorKong, Xiang Yien_US
dc.contributor.authorHolven, Kirsten Bjørklunden_US
dc.contributor.authorAukrust, Pålen_US
dc.contributor.authorFevang, Børreen_US
dc.contributor.authorJørgensen, Silje Fjellgården_US
dc.PublishedMacpherson M, Halvorsen BE, Yndestad A, Ueland T, Mollnes TE, Berge RK, Rashidi A, Otterdal K, Gregersen I, Kong XY, Holven KB, Aukrust P, Fevang B, Jørgensen S. Impaired HDL function amplifies systemic inflammation in common variable immunodeficiency. Scientific Reports. 2019;9:9427.eng
dc.description.abstractCommon variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency, characterized by inadequate antibody responses and recurrent bacterial infections. Paradoxically, a majority of CVID patients have non-infectious inflammatory and autoimmune complications, associated with systemic immune activation. Our aim was to explore if HDL, known to have anti-inflammatory properties, had impaired function in CVID patients and thereby contributed to their inflammatory phenotype. We found reduced HDL cholesterol levels in plasma of CVID patients compared to healthy controls, particularly in patients with inflammatory and autoimmune complications, correlating negatively with inflammatory markers CRP and sCD25. Reverse cholesterol transport capacity testing showed reduced serum acceptance capacity for cholesterol in CVID patients with inflammatory and autoimmune complications. They also had reduced cholesterol efflux capacity from macrophages to serum and decreased expression of ATP-binding cassette transporter ABCA1. Human HDL suppressed TLR2-induced TNF release less in blood mononuclear cells from CVID patients, associated with decreased expression of transcriptional factor ATF3. Our data suggest a link between impaired HDL function and systemic inflammation in CVID patients, particularly in those with autoimmune and inflammatory complications. This identifies HDL as a novel therapeutic target in CVID as well as other more common conditions characterized by sterile inflammation or autoimmunity.en_US
dc.publisherNature Researcheng
dc.rightsAttribution CC BY 4.0eng
dc.subjectMolecular medicineeng
dc.subjectPrimary immunodeficiency disorderseng
dc.titleImpaired HDL function amplifies systemic inflammation in common variable immunodeficiencyen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2019 The Author(s)
dc.source.journalScientific Reports

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Attribution CC BY 4.0
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