Glioma-associated epilepsy : and the treatment with antiepileptic drugs
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Background: Gliomas are primary brain tumors with a risk of epileptic seizures that especially depends on subtype. Whether epilepsy or anti-epileptic drugs (AEDs) prolong survival in patients with glioblastoma (GBM) is a matter of debate. Studies of psychiatric drug treatment after a glioma diagnosis are sparse. Previous reports on status epilepticus (SE) secondary to glioma were retrospective or included heterogeneous tumor types. Objectives: Firstly, we hypothesized that epilepsy is not favorable for the prognosis of GBM but that particular AEDs can improve the overall survival (OS). Secondly, we hypothesized that AED exposure can be associated with drug-treated anxiety or depression and that use of psychiatric medication differ between glioma patients and the general population. Thirdly, we hypothesized that SE secondary to glioma is related to tumor grade, and that the treatment response and outcome is worse with underlying tumor progression. Material and methods: Data from the Cancer registry of Norway on patients diagnosed with grade II-IV glioma 2004-2010 were linked with the Norwegian Prescription Database and the Norwegian Cause of Death Registry, with a follow-up until 2013. In paper I, we investigated OS in GBM related to AED exposure. In paper II, we examined risk factors for drug-treated anxiety and depression after a diagnosis of grade II-IV glioma. In paper III, we described clinical aspects of SE secondary to grade II-IV glioma diagnosed in two Norwegian Western counties. Results and conclusions: Neither epilepsy nor the six most commonly used AEDs in our GBM cohort were proven to affect OS. Exposure to levetiracetam was associated with drug-treated anxiety after a grade II-III glioma diagnosis. Fewer received antidepressants among the patients with grade II-III glioma and epilepsy than among the general population. SE was more frequent with higher tumor grade. Patients with tumor progression responded as well to standard SE treatment as patients with no underlying tumor progression, but had a worse outcome.
Has partsPaper I: Knudsen-Baas KM, Engeland A, Gilhus NE, Storstein A, Owe JF (2016) Does the choice of antiepileptic drug affect survival in glioblastoma patients? J Neurooncol. 129(3):461-9. The article is not available in BORA due to publisher restrictions. The published version is available at: https://doi.org/10.1007/s11060-016-2191-0.
Paper II: Knudsen-Baas KM, Johannesen TB, Myklebust TÅ, Aarseth JH, Owe JF, Gilhus NE, Storstein AM (2018) Antiepileptic and psychiatric medication in a nationwide cohort of patients with glioma WHO grade II-IV. J Neurooncol. 140(3):739-748. The article is not available in BORA due to publisher restrictions. The published version is available at: https://doi.org/10.1007/s11060-018-03007-9.
Paper III: Knudsen-Baas KM, Power KN, Engelsen BA, Hegrestad SE, Gilhus NE, Storstein A (2016) Status epilepticus secondary to glioma. Seizure 40:76-80. The article is available in the main thesis. The article is also available at: https://doi.org/10.1016/j.seizure.2016.06.013.