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dc.contributor.authorBjørndal, Bodilen_US
dc.contributor.authorAloysius, Thomas Aquinasen_US
dc.contributor.authorLund, Andersen_US
dc.contributor.authorSlizyte, Rasaen_US
dc.contributor.authorBohov, Pavolen_US
dc.contributor.authorCarvajal, Ana Karinaen_US
dc.contributor.authorBerge, Rolf Kristianen_US
dc.date.accessioned2020-03-30T14:00:01Z
dc.date.available2020-03-30T14:00:01Z
dc.date.issued2019-01-13
dc.PublishedBjørndal B, Aloysius T, Lund A, Slizyte R, Bohov P, Carvajal AK, Berge RK. A chicken protein hydrolysate exerts anti-atherosclerotic effect beyond plasma cholesterol-lowering activity in Apoe−/− mice. Food Science & Nutrition. 2019:1-9.eng
dc.identifier.issn2048-7177
dc.identifier.urihttps://hdl.handle.net/1956/21632
dc.description.abstractChicken protein hydrolysates (CPHs) generated from rest raw materials through enzymatic hydrolysis using Corolase PP or Alcalase were shown to reduce inflammation and stimulate hepatic mitochondrial fatty acid oxidation in high‐fat‐fed mice. This study investigates the effect of CPH diets in atherosclerosis‐prone apolipoprotein E‐deficient (Apoe−/−) mice. Apoe−/− mice were divided into three groups of 12 animals and fed high‐fat diets with casein (control), Alcalase CPH, or Corolase PP CPH. After 12 weeks, mice were sacrificed, blood samples were collected, and aorta was dissected for subsequent én face analysis. Mice fed Corolase PP CPH but not Alcalase CPH had significantly lower % atherosclerotic plaque area in the aortic arch compared to controls (p = .015 and p = .077, respectively). Plasma and liver cholesterol and triacylglycerol remained constant, but levels of the fatty acid C20:5n‐3 were increased, accompanied by an elevated delta‐5 desaturase index in both CPHs groups. Moreover, a significant reduction of plasma MCP‐1 was detected in Corolase PP CPH compared to control. Overall, our data show that protein hydrolysates from chicken reduced atherosclerosis and attenuated systemic risk factors related to atherosclerotic disorders, not related to changes in the level of plasma cholesterol.en_US
dc.language.isoengeng
dc.publisherWileyeng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0eng
dc.subjectAtherosclerosiseng
dc.subjectChicken protein hydrolysateeng
dc.subjectCytokineseng
dc.subjectFatty acid compositioneng
dc.subjectInflammationeng
dc.titleA chicken protein hydrolysate exerts anti-atherosclerotic effect beyond plasma cholesterol-lowering activity in Apoe−/− miceen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2020-02-05T16:03:14Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2019 The Authors
dc.identifier.doihttps://doi.org/10.1002/fsn3.1300
dc.identifier.cristin1791150
dc.source.journalFood Science & Nutrition


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