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dc.contributor.authorSangnes, Dag Andréen_US
dc.contributor.authorSøfteland, Eiriken_US
dc.contributor.authorBekkelund, Mattisen_US
dc.contributor.authorFrey, Jakuben_US
dc.contributor.authorBiermann, Martinen_US
dc.contributor.authorGilja, Odd Helgeen_US
dc.contributor.authorDimcevski, Georg Gjorgjien_US
dc.PublishedSangnes DA, Søfteland E, Bekkelund M, Frey, Biermann M, Gilja OH, Dimcevski G. Wireless motility capsule compared with scintigraphy in the assessment of diabetic gastroparesis. Neurogastroenterology and Motility. 2020;32:e13771eng
dc.description.abstractBackground: Gastroparesis is a potentially severe late complication of diabetes mellitus. Today, delayed gastric emptying (GE) is mandatory for establishing the diagnosis. In this study, we compared wireless motility capsule (WMC) with gastric emptying scintigraphy (GES). Methods: Seventy‐two patients (49 women) with diabetes mellitus (59 type 1) and symptoms compatible with gastroparesis were prospectively included between 2014 and 2018. Patients were simultaneously examined with GES and WMC. Symptoms were assessed with the Patient Assessment of Upper Gastrointestinal Symptom Severity Index (PAGI‐SYM) questionnaire. All patients were on intravenous glucose‐insulin infusion during testing. Key Results: WMC and GES correlated r = .74, P < .001. Compared to GES, WMC at ordinary cutoff for delayed GE (300 minutes) had a sensitivity of 0.92, specificity 0.73, accuracy 0.80, and Cohen's kappa κ = 0.61 (P < .001). By receiver operating characteristics (ROC), the area under the curve was 0.95 (P < .001). A cutoff value for delayed GE of 385 minutes produced sensitivity 0.92, specificity 0.83, accuracy 0.86, and Cohen's kappa κ = 0.72 (P < .001). Inter‐rater reliability for GE time with WMC was r = .996, κ = 0.97, both P < .001. There was no difference in symptom severity between patients with normal and delayed GE. Conclusions & Inferences: Our findings demonstrate the applicability of WMC as a reliable test to assess gastric emptying in diabetic gastroparesis showing very high inter‐observer correlation. By elevating the cutoff value for delayed emptying from 300 to 385 minutes, we found higher specificity without reducing sensitivity.en_US
dc.publisherJohn Wiley & Sons Ltdeng
dc.rightsAttribution CC BYeng
dc.subjectDiabetes mellituseng
dc.subjectgastric emptyingeng
dc.subjectgastric emptying scintigraphyeng
dc.subjectwireless motility capsuleeng
dc.titleWireless motility capsule compared with scintigraphy in the assessment of diabetic gastroparesisen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2019 The Author(s)
dc.source.journalNeurogastroenterology and Motility

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