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dc.contributor.authorGjerde, Priyanthi Borgenen_US
dc.contributor.authorSimonsen, Carmen Elisabethen_US
dc.contributor.authorLagerberg, Trine Viken_US
dc.contributor.authorSteen, Nils Eielen_US
dc.contributor.authorUeland, Torillen_US
dc.contributor.authorAndreassen, Ole Andreasen_US
dc.contributor.authorSteen, Vidar Martinen_US
dc.contributor.authorMelle, Ingriden_US
dc.PublishedGjerde PB, Simonsen CE, Lagerberg TV, Steen NE, Ueland T, Andreassen OA, Steen VM, Melle I. Improvement in verbal learning over the first year of antipsychotic treatment is associated with serum HDL levels in a cohort of first episode psychosis patients. European Archives of Psychiatry and Clinical Neuroscience. 2020;270:49-58eng
dc.description.abstractTo investigate whether changes in serum lipids are associated with cognitive performance in first episode psychosis (FEP) patients during their first year of antipsychotic drug treatment. One hundred and thirty-two antipsychotic-treated FEP patients were included through the TOP study along with 83 age- and gender-matched healthy controls (HC). Information regarding cognitive performance, psychotic symptoms, lifestyle, body mass index, serum lipids [total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein cholesterol, and triglycerides] and antipsychotic treatment was obtained at baseline and after 1 year. The cognitive test battery is comprised of assessments for verbal learning, processing speed, working memory, verbal fluency, and inhibition. Mixed-effects models were used to study the relationship between changes over time in serum lipids and cognitive domains, controlling for potential confounders. There was a significant group by HDL interaction effect for verbal learning (F = 11.12, p = 0.001), where an increase in HDL levels was associated with improvement in verbal learning in FEP patients but not in HC. Practice effects, lifestyle, and psychotic symptoms did not significantly affect this relationship. Antipsychotic-treated FEP patients who increased in HDL levels during the first year of follow-up exhibited better verbal learning capacity. Further investigations are needed to clarify the underlying mechanisms.en_US
dc.publisherSpringer Natureeng
dc.rightsAttribution CC BYeng
dc.titleImprovement in verbal learning over the first year of antipsychotic treatment is associated with serum HDL levels in a cohort of first episode psychosis patientsen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2019 The Authors
dc.source.journalEuropean Archives of Psychiatry and Clinical Neuroscience

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