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dc.contributor.authorBradfield, Jonathan P.en_US
dc.contributor.authorVogelezang, Suzanneen_US
dc.contributor.authorFelix, Janine F.en_US
dc.contributor.authorChesi, Alessandraen_US
dc.contributor.authorHelgeland, Øyvinden_US
dc.contributor.authorHorikoshi, Momokoen_US
dc.contributor.authorKarhunen, Villeen_US
dc.contributor.authorLowry, Estelleen_US
dc.contributor.authorCousminer, Diana L.en_US
dc.contributor.authorAhluwalia, Tarunveer S.en_US
dc.contributor.authorThiering, Elisabethen_US
dc.contributor.authorBoh, Eileen Tai-Huien_US
dc.contributor.authorZafarmand, Mohammad H.en_US
dc.contributor.authorVilor-Tejedor, Nataliaen_US
dc.contributor.authorWang, Carol A.en_US
dc.contributor.authorJoro, Raimoen_US
dc.contributor.authorChen, Zhanghuaen_US
dc.contributor.authorGauderman, William J.en_US
dc.contributor.authorPitkänen, Niinaen_US
dc.contributor.authorParra, Esteban J.en_US
dc.contributor.authorFernandez-Rhodes, Lindsayen_US
dc.contributor.authorAlyass, Akramen_US
dc.contributor.authorMonnereau, Claireen_US
dc.contributor.authorCurtin, John A.en_US
dc.contributor.authorHave, Christian T.en_US
dc.contributor.authorMcCormack, Shana E.en_US
dc.contributor.authorHollensted, Metteen_US
dc.contributor.authorFrithioff-Bøjsøe, Christineen_US
dc.contributor.authorValladares-Salgado, Adanen_US
dc.contributor.authorPeralta-Romero, Jesusen_US
dc.contributor.authorTeo, Yik-Yingen_US
dc.contributor.authorStandl, Marieen_US
dc.contributor.authorLeinonen, Jaakko T.en_US
dc.contributor.authorHolm, Jens-Christianen_US
dc.contributor.authorPeters, Triinuen_US
dc.contributor.authorVioque, Jesusen_US
dc.contributor.authorVrijheid, Martineen_US
dc.contributor.authorSimpson, Angelaen_US
dc.contributor.authorCustovic, Adnanen_US
dc.contributor.authorVaudel, Marcen_US
dc.contributor.authorCanouil, Mickaëlen_US
dc.contributor.authorLindi, Virpien_US
dc.contributor.authorAtalay, Mustafaen_US
dc.contributor.authorKahonen, Mikaen_US
dc.contributor.authorRaitakari, Olli T.en_US
dc.contributor.authorvan Schaik, Barbera D.C.en_US
dc.contributor.authorBerkowitz, Robert I.en_US
dc.contributor.authorCole, Shelley A.en_US
dc.contributor.authorVoruganti, V. Sarojaen_US
dc.contributor.authorWang, Yujieen_US
dc.contributor.authorHighland, Heather M.en_US
dc.contributor.authorComuzzie, Anthony G.en_US
dc.contributor.authorButte, Nancy F.en_US
dc.contributor.authorJustice, Anne E.en_US
dc.contributor.authorGahagan, Sheilaen_US
dc.contributor.authorBlanco, Estelaen_US
dc.contributor.authorLehtimäki, Terhoen_US
dc.contributor.authorLakka, Timo A.en_US
dc.contributor.authorHebebrand, Johannesen_US
dc.contributor.authorBonnefond, Amélieen_US
dc.contributor.authorGrarup, Nielsen_US
dc.contributor.authorFroguel, Philippeen_US
dc.contributor.authorLyytikäinen, Leo-Pekkaen_US
dc.contributor.authorCruz, Miguelen_US
dc.contributor.authorKobes, Sayukoen_US
dc.contributor.authorHanson, Robert L.en_US
dc.contributor.authorZemel, Babette S.en_US
dc.contributor.authorHinney, Ankeen_US
dc.contributor.authorTeo, Koon K.en_US
dc.contributor.authorMeyre, Daviden_US
dc.contributor.authorNorth, Kari E.en_US
dc.contributor.authorGilliland, Frank D.en_US
dc.contributor.authorBisgaard, Hansen_US
dc.contributor.authorBustamante, Marionaen_US
dc.contributor.authorBønnelykke, Klausen_US
dc.contributor.authorPennell, Craig E.en_US
dc.contributor.authorRivadeneira, Fernandoen_US
dc.contributor.authorUitterlinden, André G.en_US
dc.contributor.authorBaier, Leslie J.en_US
dc.contributor.authorVrijkotte, Tanja G.M.en_US
dc.contributor.authorHeinrich, Joachimen_US
dc.contributor.authorSørensen, Thorkild I.A.en_US
dc.contributor.authorSaw, Seang-Meien_US
dc.contributor.authorPedersen, Olufen_US
dc.contributor.authorHansen, Torbenen_US
dc.contributor.authorEriksson, Johanen_US
dc.contributor.authorWidén, Elisabethen_US
dc.contributor.authorMcCarthy, Mark I.en_US
dc.contributor.authorNjølstad, Pål Rasmusen_US
dc.contributor.authorPower, Christineen_US
dc.contributor.authorHyppönen, Elinaen_US
dc.contributor.authorSebert, Sylvainen_US
dc.contributor.authorBrown, Christopher D.en_US
dc.contributor.authorJärvelin, Marjo-Riittaen_US
dc.contributor.authorTimpson, Nicholas J.en_US
dc.contributor.authorJohansson, Stefanen_US
dc.contributor.authorHakonarson, Hakonen_US
dc.contributor.authorJaddoe, Vincent W.V.en_US
dc.date.accessioned2020-05-05T14:02:06Z
dc.date.available2020-05-05T14:02:06Z
dc.date.issued2019
dc.PublishedBradfield JP, Vogelezang S, Felix JF, Chesi A, Helgeland Ø, Horikoshi M, et al. A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity. Human Molecular Genetics. 2019;28(19):3327-3338eng
dc.identifier.issn0964-6906
dc.identifier.issn1460-2083
dc.identifier.urihttps://hdl.handle.net/1956/22099
dc.descriptionUnder embargo until: 2020-06-08en_US
dc.description.abstractAlthough hundreds of genome-wide association studies-implicated loci have been reported for adult obesity-related traits, less is known about the genetics specific for early-onset obesity and with only a few studies conducted in non-European populations to date. Searching for additional genetic variants associated with childhood obesity, we performed a trans-ancestral meta-analysis of 30 studies consisting of up to 13 005 cases (≥95th percentile of body mass index (BMI) achieved 2–18 years old) and 15 599 controls (consistently <50th percentile of BMI) of European, African, North/South American and East Asian ancestry. Suggestive loci were taken forward for replication in a sample of 1888 cases and 4689 controls from seven cohorts of European and North/South American ancestry. In addition to observing 18 previously implicated BMI or obesity loci, for both early and late onset, we uncovered one completely novel locus in this trans-ancestral analysis (nearest gene, METTL15). The variant was nominally associated with only the European subgroup analysis but had a consistent direction of effect in other ethnicities. We then utilized trans-ancestral Bayesian analysis to narrow down the location of the probable causal variant at each genome-wide significant signal. Of all the fine-mapped loci, we were able to narrow down the causative variant at four known loci to fewer than 10 single nucleotide polymorphisms (SNPs) (FAIM2, GNPDA2, MC4R and SEC16B loci). In conclusion, an ethnically diverse setting has enabled us to both identify an additional pediatric obesity locus and further fine-map existing loci.en_US
dc.language.isoengeng
dc.publisherOxford University Presseng
dc.titleA trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesityen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2020-02-07T08:36:13Z
dc.description.versionacceptedVersionen_US
dc.rights.holderCopyright The Author(s) 2019. Published by Oxford University Press. All rights reserved.
dc.identifier.doihttps://doi.org/10.1093/hmg/ddz161
dc.identifier.cristin1763610
dc.source.journalHuman Molecular Genetics


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