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dc.contributor.authorMikalsen, Ingvild Bruunen_US
dc.contributor.authorDalen, Ingvilden_US
dc.contributor.authorKarlstad, Øysteinen_US
dc.contributor.authorEide, Geir Egilen_US
dc.contributor.authorMagnus, Maria Christineen_US
dc.contributor.authorNystad, Wencheen_US
dc.contributor.authorØymar, Knuten_US
dc.PublishedMikalsen IB, Dalen I, Karlstad Ø, Eide GE, Magnus MC, Nystad W, Øymar K. Airway symptoms and atopy in young children prescribed asthma medications: A large‐scale cohort study. Pediatric Pulmonology. 2019;54(10):1557-1566eng
dc.description.abstractDiagnosing asthma and deciding treatment are difficult in young children. An inappropriate and too high prescription rate of inhaled corticosteroids (ICS) is suggested, but how airway symptoms are associated with prescriptions of asthma medication is less known. We studied how strongly wheeze, lower respiratory tract infections (LRTI), and atopic diseases are associated with dispensing of asthma medications during early childhood. We used data from the Norwegian Mother and Child Cohort Study and the Norwegian Prescription Database at four age‐intervals (0‐6, 6‐18, 18‐36 months, and 3‐7 years). Primary outcomes were dispensed asthma medications (no medication, short‐acting β‐2 agonist, or ICS). Relative risks (RRs) and average attributable fractions (AAFs) were estimated. Both wheeze and LRTI were positively associated with both medication groups (0‐6 months: no data on wheeze). The RRs and AAFs were higher for wheeze than LRTI. For ICS, the AAFs (95% CI) for wheeze vs LRTI were: 6 to 18 months: 69.2 (67.2, 71.2)% vs 10.4 (9.0, 11.8)%, 18 to 36 months: 33.0 (30.5, 35.5)% vs 10.0 (8.0, 12.0)%, and 3 to 7 years: 33.7 (31.0, 36.5)% vs 1.2 (0.5, 1.9)%. Except at 3 to 7 years of age, the AAFs were lower for atopic diseases than for LRTI and wheeze. Atopic diseases modified the associations between wheeze and ICS at 18 to 36 months and between LRTI or wheeze and ICS at 3 to 7 years. In conclusion, both wheeze and LRTI were associated with prescriptions of asthma medications in young children, with the strongest associations seen for wheeze. Atopic diseases contributed to these associations only in the oldest age groups.en_US
dc.rightsAttribution-Non Commercial CC BY-NCeng
dc.titleAirway symptoms and atopy in young children prescribed asthma medications: A large‐scale cohort studyen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2019 The Authors
dc.source.journalPediatric Pulmonology

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