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dc.contributor.authorMäki-Marttunen, Tuomoen_US
dc.contributor.authorKrull, Florianen_US
dc.contributor.authorBettella, Francescoen_US
dc.contributor.authorHagen, Espenen_US
dc.contributor.authorNæss, Solveigen_US
dc.contributor.authorNess, Torbjørn Ven_US
dc.contributor.authorMoberget, Torgeiren_US
dc.contributor.authorElvsåshagen, Torbjørnen_US
dc.contributor.authorMetzner, Christophen_US
dc.contributor.authorDevor, Annaen_US
dc.contributor.authorEdwards, Andrew G.en_US
dc.contributor.authorFyhn, Marianneen_US
dc.contributor.authorDjurovic, Srdjanen_US
dc.contributor.authorDale, Andersen_US
dc.contributor.authorAndreassen, Ole Andreasen_US
dc.contributor.authorEinevoll, Gauteen_US
dc.PublishedMäki-Marttunen T, Krull F, Bettella F, Hagen E, Næss S, et al. Alterations in schizophrenia-associated genes can lead to increased power in delta oscillations. Cerebral Cortex. 2019;29(2):875-891eng
dc.description.abstractGenome-wide association studies have implicated many ion channels in schizophrenia pathophysiology. Although the functions of these channels are relatively well characterized by single-cell studies, the contributions of common variation in these channels to neurophysiological biomarkers and symptoms of schizophrenia remain elusive. Here, using computational modeling, we show that a common biomarker of schizophrenia, namely, an increase in delta-oscillation power, may be a direct consequence of altered expression or kinetics of voltage-gated ion channels or calcium transporters. Our model of a circuit of layer V pyramidal cells highlights multiple types of schizophrenia-related variants that contribute to altered dynamics in the delta-frequency band. Moreover, our model predicts that the same membrane mechanisms that increase the layer V pyramidal cell network gain and response to delta-frequency oscillations may also cause a deficit in a single-cell correlate of the prepulse inhibition, which is a behavioral biomarker highly associated with schizophrenia.en_US
dc.publisherOxford University Presseng
dc.rightsAttribution-NonCommercial CC BY-NCeng
dc.subjectforward modeling of EEGeng
dc.subjectfunctional genomicseng
dc.subjection channelseng
dc.subjectmulticompartmental neuron modelingeng
dc.subjectschizophrenia geneticseng
dc.titleAlterations in schizophrenia-associated genes can lead to increased power in delta oscillationsen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2018 The Author(s)
dc.source.journalCerebral Cortex

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