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dc.contributor.authorScott, Janen_US
dc.contributor.authorHidalgo-Mazzei, Diegoen_US
dc.contributor.authorStrawbridge, Rebeccaen_US
dc.contributor.authorYoung, Allanen_US
dc.contributor.authorResche-Rigon, Matthieuen_US
dc.contributor.authorEtain, Brunoen_US
dc.contributor.authorAndreassen, Ole Andreasen_US
dc.contributor.authorBauer, Michaelen_US
dc.contributor.authorBennabi, Djamilaen_US
dc.contributor.authorBlamire, Andrew M.en_US
dc.contributor.authorBoumezbeur, Fawzien_US
dc.contributor.authorBrambilla, Paoloen_US
dc.contributor.authorCattane, Nadiaen_US
dc.contributor.authorCattaneo, Annamariaen_US
dc.contributor.authorChupin, Marieen_US
dc.contributor.authorCoello, Klaraen_US
dc.contributor.authorCointepas, Yannen_US
dc.contributor.authorColom, Francescen_US
dc.contributor.authorCousins, David A.en_US
dc.contributor.authorDubertret, Carolineen_US
dc.contributor.authorDuchesnay, Edouarden_US
dc.contributor.authorFerro, Adeleen_US
dc.contributor.authorGarcia-Estela, Aitanaen_US
dc.contributor.authorGoikolea, Joseen_US
dc.contributor.authorGrigis, Antoineen_US
dc.contributor.authorHaffen, Emmanuelen_US
dc.contributor.authorHøegh, Margrethe Collieren_US
dc.contributor.authorJakobsen, Petteren_US
dc.contributor.authorKalman, Janos L.en_US
dc.contributor.authorKessing, Lars V.en_US
dc.contributor.authorKlohn-Saghatolislam, Farahen_US
dc.contributor.authorLagerberg, Trine Viken_US
dc.contributor.authorLandén, Mikaelen_US
dc.contributor.authorLewitzka, Uteen_US
dc.contributor.authorLutticke, Ashleyen_US
dc.contributor.authorMazer, Nicolasen_US
dc.contributor.authorMazzelli, Monicaen_US
dc.contributor.authorMora, Cristinaen_US
dc.contributor.authorMuller, Thorstenen_US
dc.contributor.authorMur-Mila, Estanislaoen_US
dc.contributor.authorØdegaard, Ketil Joachimen_US
dc.contributor.authorOltedal, Leifen_US
dc.contributor.authorPålsson, Eriken_US
dc.contributor.authorPapadopoulos Orfanos, Dimitrien_US
dc.contributor.authorPapiol, Sergien_US
dc.contributor.authorPerez-Sola, Victoren_US
dc.contributor.authorReif, Andreasen_US
dc.contributor.authorRitter, Philippen_US
dc.contributor.authorRossi, Robertoen_US
dc.contributor.authorSchulze, Thomasen_US
dc.contributor.authorSenner, Fannyen_US
dc.contributor.authorSmith, Fiona E.en_US
dc.contributor.authorSquarcina, Letiziaen_US
dc.contributor.authorSteen, Nils Eielen_US
dc.contributor.authorThelwall, Pete E.en_US
dc.contributor.authorVaro, Cristinaen_US
dc.contributor.authorVieta, Eduarden_US
dc.contributor.authorVinberg, Majen_US
dc.contributor.authorWessa, Micheleen_US
dc.contributor.authorWestlye, Lars Tjeltaen_US
dc.contributor.authorBellivier, Franken_US
dc.PublishedScott J, Hidalgo-Mazzei, Strawbridge, Young, Resche-Rigon, Etain B, Andreassen OA, Bauer M, Bennabi, Blamire, Boumezbeur, Brambilla P, Cattane, Cattaneo A, Chupin, Coello, Cointepas, Colom F, Cousins, Dubertret, Duchesnay E, Ferro A, Garcia-Estela, Goikolea, Grigis, Haffen, Høegh MC, Jakobsen P, Kalman, Kessing, Klohn-Saghatolislam, Lagerberg TV, Landén M, Lewitzka U, Lutticke, Mazer, Mazzelli, Mora C, Muller, Mur-Mila, Ødegaard KJ, Oltedal L, Pålsson E, Papadopoulos Orfanos D, Papiol, Perez-Sola, Reif A, Ritter P, Rossi R, Schulze T, Senner, Smith, Squarcina, Steen NE, Thelwall, Varo, Vieta E, Vinberg, Wessa, Westlye LT, Bellivier F. Prospective cohort study of early biosignatures of response to lithium in bipolar-I-disorders: overview of the H2020-funded R-LiNK initiative. International journal of bipolar disorders. 2019;7(1):20eng
dc.description.abstractBackground Lithium is recommended as a first line treatment for bipolar disorders. However, only 30% of patients show an optimal outcome and variability in lithium response and tolerability is poorly understood. It remains difficult for clinicians to reliably predict which patients will benefit without recourse to a lengthy treatment trial. Greater precision in the early identification of individuals who are likely to respond to lithium is a significant unmet clinical need. Structure The H2020-funded Response to Lithium Network (R-LiNK; will undertake a prospective cohort study of over 300 individuals with bipolar-I-disorder who have agreed to commence a trial of lithium treatment following a recommendation by their treating clinician. The study aims to examine the early prediction of lithium response, non-response and tolerability by combining systematic clinical syndrome subtyping with examination of multi-modal biomarkers (or biosignatures), including omics, neuroimaging, and actigraphy, etc. Individuals will be followed up for 24 months and an independent panel will assess and classify each participants’ response to lithium according to predefined criteria that consider evidence of relapse, recurrence, remission, changes in illness activity or treatment failure (e.g. stopping lithium; new prescriptions of other mood stabilizers) and exposure to lithium. Novel elements of this study include the recruitment of a large, multinational, clinically representative sample specifically for the purpose of studying candidate biomarkers and biosignatures; the application of lithium-7 magnetic resonance imaging to explore the distribution of lithium in the brain; development of a digital phenotype (using actigraphy and ecological momentary assessment) to monitor daily variability in symptoms; and economic modelling of the cost-effectiveness of introducing biomarker tests for the customisation of lithium treatment into clinical practice. Also, study participants with sub-optimal medication adherence will be offered brief interventions (which can be delivered via a clinician or smartphone app) to enhance treatment engagement and to minimize confounding of lithium non-response with non-adherence. Conclusions The paper outlines the rationale, design and methodology of the first study being undertaken by the newly established R-LiNK collaboration and describes how the project may help to refine the clinical response phenotype and could translate into the personalization of lithium treatment.en_US
dc.rightsAttribution CC BYeng
dc.titleProspective cohort study of early biosignatures of response to lithium in bipolar-I-disorders: overview of the H2020-funded R-LiNK initiativeen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2019 The Author(s)
dc.source.journalInternational journal of bipolar disorders

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