dc.contributor.author | Varhaug, Kristin Nielsen | en_US |
dc.contributor.author | Torkildsen, Øivind | en_US |
dc.contributor.author | Myhr, Kjell-Morten | en_US |
dc.contributor.author | Vedeler, Christian A. | en_US |
dc.date.accessioned | 2020-06-15T16:00:27Z | |
dc.date.available | 2020-06-15T16:00:27Z | |
dc.date.issued | 2019-04-05 | |
dc.Published | Varhaug K, Torkildsen Ø, Myhr KM, Vedeler CA. Neurofilament light chain as a biomarker in multiple sclerosis. Frontiers in Neurology. 2019;10:338 | eng |
dc.identifier.issn | 1664-2295 | |
dc.identifier.uri | https://hdl.handle.net/1956/22600 | |
dc.description.abstract | Due to the unpredictable course and heterogenous treatment response in multiple sclerosis (MS), there is a clear need for biomarkers that reflect disease activity in the clinical follow-up of these patients. Neurofilaments are neuron-specific components of the cytoskeleton that can be assayed in different body compartments. They have been explored as potential biomarkers for many years. Neurofilament light chain (NF-L) appears the most promising biomarker in MS patients, and there is now little doubt that NF-L should have a role in the follow-up of MS patients. Newer assays and techniques for NF-L detection available in serum samples confirms the usefulness of NF-L as a biomarker. Nevertheless, there is still a need for prospective studies, and studies to determine clinical useful cut-off values. This review evaluates the strengths and weaknesses of NF-L as a biomarker in patients with MS. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Frontiers | eng |
dc.rights | Attribution CC BY | eng |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | eng |
dc.title | Neurofilament light chain as a biomarker in multiple sclerosis | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2019-12-13T12:30:23Z | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2019 Varhaug, Torkildsen, Myhr and Vedeler | |
dc.identifier.doi | https://doi.org/10.3389/fneur.2019.00338 | |
dc.identifier.cristin | 1719545 | |
dc.source.journal | Frontiers in Neurology | |