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dc.contributor.authorGudbrandsen, Oddrun Anitaen_US
dc.contributor.authorDankel, Simon Nen_US
dc.contributor.authorSkumsnes, Lillianen_US
dc.contributor.authorFlølo, Tone Nygaarden_US
dc.contributor.authorFolkestad, Oddry Hen_US
dc.contributor.authorNielsen, Hans Jørgenen_US
dc.contributor.authorVåge, Villyen_US
dc.contributor.authorMohn, Arne-Christianen_US
dc.contributor.authorNedrebø, Bjørn Gunnaren_US
dc.contributor.authorSagen, Jørn V.en_US
dc.contributor.authorFernø, Johanen_US
dc.contributor.authorMellgren, Gunnaren_US
dc.date.accessioned2020-06-17T13:37:56Z
dc.date.available2020-06-17T13:37:56Z
dc.date.issued2019-10-15
dc.PublishedGudbrandsen OA, Dankel SND, Skumsnes L, Flølo TN, et al. Short-term effects of Vertical sleeve gastrectomy and Roux-en-Y gastric bypass on glucose homeostasis. Scientific Reports. 2019;9:14817eng
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/1956/22684
dc.description.abstractThe objective of this study was to compare the biochemical changes related to glucose tolerance and lipid metabolism in non-diabetic patients shortly after vertical sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB). Non-diabetic women and men with morbid obesity were studied the day before and six days after SG (N = 15) or RYGB (N = 16). Patients completed an oral glucose tolerance test (OGTT; 75 g glucose) at both visits. SG and RYGB similarly improved fasting glucose homeostasis six days after surgery, with reduced glucose and insulin concentrations. The OGTT revealed differences between the two surgery groups that were not evident from the fasting serum concentrations. Postprandial (120 min) glucose and insulin concentrations were lower after RYGB but not after SG, whereas concentrations of glucagon-like peptide-1, peptide YY, glucagon and non-esterified fatty acids were elevated after both SG and RYGB. Fasting triacylglycerol concentration did not change after surgery, but concentrations of high density lipoprotein and low density lipoprotein cholesterols were reduced in both surgery groups, with no differences between the groups. To conclude, RYGB induced a more pronounced improvement in postprandial glucose homeostasis relative to SG, possibly due to improved insulin sensitivity rather than augmented insulin concentration.en_US
dc.language.isoengeng
dc.publisherSpringereng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/eng
dc.titleShort-term effects of Vertical sleeve gastrectomy and Roux-en-Y gastric bypass on glucose homeostasisen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2019-12-13T14:06:22Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2019 The Author(s)
dc.identifier.doihttps://doi.org/10.1038/s41598-019-51347-x
dc.identifier.cristin1743537
dc.source.journalScientific Reports


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