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dc.contributor.authorTriebner, Kaien_US
dc.contributor.authorAccordini, Simoneen_US
dc.contributor.authorCalciano, Luciaen_US
dc.contributor.authorJohannessen, Aneen_US
dc.contributor.authorBenediktsdóttir, Bryndísen_US
dc.contributor.authorBifulco, Ersiliaen_US
dc.contributor.authorDemoly, Pascalen_US
dc.contributor.authorDharmage, Shyamali C.en_US
dc.contributor.authorFranklin, Karl A.en_US
dc.contributor.authorGarcia-Aymerich, Judithen_US
dc.contributor.authorGullón Blanco, José Antonioen_US
dc.contributor.authorHeinrich, Joachimen_US
dc.contributor.authorHolm, Mathiasen_US
dc.contributor.authorJarvis, Debbieen_US
dc.contributor.authorJõgi, Rainen_US
dc.contributor.authorLindberg, Evaen_US
dc.contributor.authorMartínez-Moratalla, Jesúsen_US
dc.contributor.authorMuniozguren Agirre, Nereaen_US
dc.contributor.authorPin, Isabelleen_US
dc.contributor.authorProbst-Hensch, Nicoleen_US
dc.contributor.authorRaherison, Chantalen_US
dc.contributor.authorSánchez-Ramos, José Luisen_US
dc.contributor.authorSchlünssen, Vivien_US
dc.contributor.authorSvanes, Cecilieen_US
dc.contributor.authorHustad, Simon Steinaren_US
dc.contributor.authorLeynaert, Bénédicteen_US
dc.contributor.authorGomez Real, Franciscoen_US
dc.PublishedTriebner K, Accordini S, Calciano L, Johannessen A, Benediktsdóttir B, Bifulco E, Demoly P, Dharmage SC, Franklin KA, Garcia-Aymerich J, Gullón Blanco JA, Heinrich J, Holm M, Jarvis D, Jõgi R, Lindberg E, Martínez-Moratalla J, Muniozguren Agirre, Pin I, Probst-Hensch N, Raherison C, Sánchez-Ramos JL, Schlünssen V, Svanes C, Hustad S, Leynaert B, Gomez Real F. Exogenous female sex steroids may reduce lung ageing after menopause: A 20-year follow-up study of a general population sample (ECRHS). Maturitas. 2019;120:29-34eng
dc.description.abstractObjectives: Menopause involves hypoestrogenism, which is associated with numerous detrimental effects, including on respiratory health. Hormone replacement therapy (HRT) is often used to improve symptoms of menopause. The effects of HRT on lung function decline, hence lung ageing, have not yet been investigated despite the recognized effects of HRT on other health outcomes. Study design: The population-based multi-centre European Community Respiratory Health Survey provided complete data for 275 oral HRT users at two time points, who were matched with 383 nonusers and analysed with a two-level linear mixed effects regression model. Main outcome measures: We studied whether HRT use was associated with the annual decline in forced vital capacity (FVC) and forced expiratory volume in one second (FEV1). Results: Lung function of women using oral HRT for more than five years declined less rapidly than that of nonusers. The adjusted difference in FVC decline was 5.6 mL/y (95%CI: 1.8 to 9.3, p = 0.01) for women who had taken HRT for six to ten years and 8.9 mL/y (3.5 to 14.2, p = 0.003) for those who had taken it for more than ten years. The adjusted difference in FEV1 decline was 4.4 mL/y (0.9 to 8.0, p = 0.02) with treatment from six to ten years and 5.3 mL/y (0.4 to 10.2, p = 0.048) with treatment for over ten years. Conclusions: In this longitudinal population-based study, the decline in lung function was less rapid in women who used HRT, following a dose-response pattern, and consistent when adjusting for potential confounding factors. This may signify that female sex hormones are of importance for lung ageing.en_US
dc.rightsAttribution-NonCommercial-NoDerivs CC BY-NC-NDeng
dc.titleExogenous female sex steroids may reduce lung ageing after menopause: A 20-year follow-up study of a general population sample (ECRHS)en_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2018 The Author(s)

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