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dc.contributor.authorWyres, Kelly L.en_US
dc.contributor.authorHawkey, Janeen_US
dc.contributor.authorHetland, Mariten_US
dc.contributor.authorFostervold, Aasmunden_US
dc.contributor.authorWick, Ryan R.en_US
dc.contributor.authorJudd, Louise M.en_US
dc.contributor.authorHamidian, Mohammaden_US
dc.contributor.authorHowden, Benjamin P.en_US
dc.contributor.authorLöhr, Iren Høylanden_US
dc.contributor.authorHolt, Kathryn E.en_US
dc.PublishedWyres, Hawkey, Hetland M, Fostervold A, Wick, Judd, Hamidian, Howden, Löhr IH, Holt KE. Emergence and rapid global dissemination of CTX-M-15-associated Klebsiella pneumoniae strain ST307. Journal of Antimicrobial Chemotherapy. 2019;74(3):577-581eng
dc.description.abstractObjectives: Recent reports indicate the emergence of a new carbapenemase-producing Klebsiella pneumoniae clone, ST307. We sought to better understand the global epidemiology and evolution of this clone and evaluate its association with antimicrobial resistance (AMR) genes. Methods: We collated information from the literature and public databases and performed a comparative analysis of 95 ST307 genomes (including 37 that were newly sequenced). Results: We show that ST307 emerged in the mid-1990s (nearly 20 years prior to its first report), is already globally distributed and is intimately associated with a conserved plasmid harbouring the blaCTX-M-15 ESBL gene and several other AMR determinants. Conclusions: Our findings support the need for enhanced surveillance of this widespread ESBL clone in which carbapenem resistance has occasionally emerged.en_US
dc.publisherOxford University Presseng
dc.rightsAttribution CC BYeng
dc.titleEmergence and rapid global dissemination of CTX-M-15-associated Klebsiella pneumoniae strain ST307en_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2018 The Authors
dc.source.journalJournal of Antimicrobial Chemotherapy

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