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dc.contributor.authorGrimstad, Toreen_US
dc.contributor.authorKvivik, Ingeborgen_US
dc.contributor.authorKvaløy, Jan Terjeen_US
dc.contributor.authorAabakken, Larsen_US
dc.contributor.authorOmdal, Roalden_US
dc.PublishedGrimstad T, Kvivik I, Kvaløy JT, Aabakken L, Omdal R. Heat-shock protein 90α in plasma reflects severity of fatigue in patients with Crohn’s disease. Innate Immunity. 2020;26(2):146–151eng
dc.description.abstractHeat-shock proteins (HSPs) are evolutionarily conserved proteins with important cellular homeostasis functions during harmful conditions, including inflammation. Some HSPs are secreted extracellularly and act on distant cells by down-regulating inflammation and increasing cellular stress defence mechanisms. HSP90α has been postulated to signal fatigue in chronic inflammation. We investigated whether HSP90α is associated with fatigue in patients with Crohn’s disease. Fifty-three patients with newly diagnosed Crohn’s disease were included in a cross-sectional study. Data on demographics and disease distribution were obtained. Fatigue was measured by the fatigue visual analogue scale (fVAS). Disease activity was assessed by the Simple Endoscopic Score for Crohn’s disease and Harvey Bradshaw Index. C-reactive protein, faecal calprotectin and HSP90α were also measured. The median fVAS score was 52 mm, indicating significant fatigue. HSP90α scores correlated significantly with fVAS (r = 0.31, P = 0.03). In a multivariate regression model, HSP90α was the only significant contributor to fVAS scores (β = 0.31, P = 0.03). When patients were dichotomised into groups with high and low HSP90α concentrations, significantly higher fVAS scores were demonstrated in the group with high HSP90α (M = 62.4, confidence interval 53.0–71.8 vs. 43.3, 31.6–55.0; P = 0.01). Thus, HSP90α may contribute to fatigue generation and/or modulation in patients with Crohn’s disease.en_US
dc.rightsAttribution-NonCommercial CC BY-NCeng
dc.titleHeat-shock protein 90α in plasma reflects severity of fatigue in patients with Crohn’s diseaseen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2019 The Author(s)
dc.source.journalInnate Immunity

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