Show simple item record

dc.contributor.authorLandsend, Erlend Christoffer Sommeren_US
dc.contributor.authorPedersen, Hilde Røgebergen_US
dc.contributor.authorUtheim, Øygunn Aassen_US
dc.contributor.authorRueegg, Corina Silviaen_US
dc.contributor.authorBaraas, Rigmor C.en_US
dc.contributor.authorLagali, Neilen_US
dc.contributor.authorBragadottir, Ragnheiduren_US
dc.contributor.authorMoe, Morten Carstenen_US
dc.contributor.authorUtheim, Tor Paaskeen_US
dc.PublishedLandsend ECS, Pedersen HR, Utheim ØA, Rueegg CS, Baraas R. C., Lagali N, Bragadottir R, Moe MC, Utheim TP. Characteristics and Utility of Fundus Autofluorescence in Congenital Aniridia Using Scanning Laser Ophthalmoscopy. Investigative Ophthalmology and Visual Science. 2019;60(13):4120-4128eng
dc.description.abstractPurpose: To investigate fundus autofluorescence (FAF) and other fundus manifestations in congenital aniridia. Methods: Fourteen patients with congenital aniridia and 14 age- and sex-matched healthy controls were examined. FAF images were obtained with an ultra-widefield scanning laser ophthalmoscope. FAF intensity was quantified in the macular fovea and in a macular ring surrounding fovea and related to an internal reference within each image. All aniridia patients underwent an ophthalmologic examination, including optical coherence tomography and slit-lamp biomicroscopy. Results: Mean age was 28.4 ± 15.0 years in both the aniridia and control groups. Fovea could be defined by subjective assessment of FAF images in three aniridia patients (21.4%) and in all controls (P = 0.001). Mean ratio between FAF intensity in the macular ring and fovea was 1.01 ± 0.15 in aniridia versus 1.18 ± 0.09 in controls (P = 0.034). In aniridia, presence of foveal hypoplasia evaluated by biomicroscopy correlated with lack of foveal appearance by subjective analyses of FAF images (P = 0.031) and observation of nystagmus (P = 0.009). Conclusions: Aniridia patients present a lower ratio between FAF intensity in the peripheral and central macula than do healthy individuals. Both subjective and objective analyses of FAF images are useful tools in evaluation of foveal hypoplasia in aniridia.en_US
dc.publisherAssociation for Research in Vision and Ophthalmologyeng
dc.rightsAttribution-Non Commercial-No Derivatives CC BY-NC-NDeng
dc.titleCharacteristics and Utility of Fundus Autofluorescence in Congenital Aniridia Using Scanning Laser Ophthalmoscopyen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2019 The Authors
dc.source.journalInvestigative Ophthalmology and Visual Science
dc.relation.projectEC/FP7: 609020

Files in this item


This item appears in the following Collection(s)

Show simple item record

Attribution-Non Commercial-No Derivatives CC BY-NC-ND
Except where otherwise noted, this item's license is described as Attribution-Non Commercial-No Derivatives CC BY-NC-ND