Show simple item record

dc.contributor.authorSangnes, Dag Andréen_US
dc.contributor.authorSofteland, Eiriken_US
dc.contributor.authorTeigland, Tonjeen_US
dc.contributor.authorDimcevski, Georg Gjorgjien_US
dc.PublishedSangnes DA, Softeland E, Teigland T, Dimcevski G. Comparing radiopaque markers and 13C-labelled breath test in diabetic gastroparesis diagnostics. Clinical and Experimental Gastroenterology. 2019;12:193-201eng
dc.description.abstractPurpose: Determining gastric emptying is mandatory in the diagnosis of diabetic gastroparesis. Several methods of investigation exist, but none has proven reliable, inexpensive and accessible. In this study, we aimed to compare gastric emptying of radiopaque markers (ROM) and 13carbon-labelled gastric emptying breath tests for solids (GEBT). We also aimed to determine any association between gastric emptying and patient-reported symptoms, glycemic control and the patients’ age, diabetes duration and occurrence of other late complications. Patients and methods: Forty-five patients (30 women, 15 men) with diabetes mellitus types 1 or 2 (40, 5) and symptoms of gastroparesis were examined with ROM and GEBT. All were interviewed, filled out symptom questionnaires and had HbA1c levels measured. Results: Forty percent of patients had delayed gastric emptying of ROM, while 55% had delayed gastric emptying of GEBT. Correlation between ROM and GEBT was not significant. Compared to GEBT, sensitivity for a positive ROM test was 0.52, while specificity was 0.74. In women, we found a higher specificity of 0.92, sensitivity 0.47. Difference in HbA1c between patients with positive and negative results was of borderline significance for both tests. GEBT (r=0.41, P=0.008) correlated with HbA1c. Patients with any late complications of diabetes had higher gastric retention of ROM (P=0.028), while patients with polyneuropathy (P=0.014) and diabetic wounds (P=0.004) had slower emptying with GEBT. None of the methods identified significant associations between gastric emptying and symptom scores, age or diabetes duration. Conclusions: As a measure of gastric emptying, the ROM test has benefits of being affordable and available. Compared to GEBT, the method has low diagnostic reliability. Before continued use, we recommend additional studies validating the test in diabetes patients.en_US
dc.publisherDove Medical Presseng
dc.rightsAttribution-Non Commercial CC BY-NCeng
dc.titleComparing radiopaque markers and 13C-labelled breath test in diabetic gastroparesis diagnosticsen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2019 The Authors
dc.source.journalClinical and Experimental Gastroenterology

Files in this item


This item appears in the following Collection(s)

Show simple item record

Attribution-Non Commercial CC BY-NC
Except where otherwise noted, this item's license is described as Attribution-Non Commercial CC BY-NC