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Parenteral Vaccination against Influenza Does Not Induce a Local Antigen-Specific Immune Response in the Nasal Mucosa

Brokstad, Karl Albert; Eriksson, Jens-Christian Haug; Cox, Rebecca Jane; Tynning, Turid Liv; Olofsson, Jan; Jonsson, Roland; Davidsson, Åke
Peer reviewed, Journal article
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https://hdl.handle.net/1956/3452
Utgivelsesdato
2002-03-19
Metadata
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  • Department of Clinical Medicine [1534]
Originalversjon
https://doi.org/10.1086/339710
Sammendrag
The immune response in the nasal mucosa to influenza vaccination in 23 patients scheduled for tonsillectomy was studied. A statistically significant increase in influenza virus–specific serum and oral fluid antibodies was observed 7 days after vaccination. The numbers of influenza virus– specific antibody-secreting cells (ASCs) in peripheral blood also increased significantly 1 week after vaccination. The numbers of ASCs in tonsils and nasal mucosa were compared with data from a recent study of nonvaccinated volunteers. The numbers of influenza virus–specific ASCs in tonsils were significantly higher in the vaccinated group, but, surprisingly, there was no significant difference between the groups in the numbers of ASCs in nasal mucosa. This suggests that the influenza virus–specific antibodies detected in oral fluid are not produced locally in the nasal mucosa and may originate from a systemic source, indicating that the vaccination may favor a systemic immune response.
Utgiver
University of Chicago Press
Opphavsrett
The Infectious Diseases Society of America

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