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dc.contributor.authorZubac, Dragomiren_US
dc.contributor.authorBostad, Leifen_US
dc.contributor.authorSeidal, Tomasen_US
dc.contributor.authorWentzel-Larsen, Toreen_US
dc.contributor.authorHaukaas, Svein Andreasen_US
dc.PublishedBMC Urology 8(19)en
dc.description.abstractBackground: To investigate a possible prognostic significance of interactions between lymph node invasion (LNI), synchronous distant metastases (SDM), and venous invasion (VI) adjusted for mode of detection, Eastern Cooperative Oncology Group performance status (ECOG PS), erythrocyte sedimentation rate (ESR) and tumour size (TS) in 196 patients with renal cell carcinoma treated with radical nephrectomy. Methods: Median follow-up was 5.5 years (mean 6.9 years; range 0.01–19.4). The mode of detection, ECOG PS, ESR and TS were obtained from the patients' records. Vena cava invasion and distant metastases were detected by preoperative imaging. The surgical specimens were examined for pathological stage, LNI and VI. Results: The univariate analyses showed significant impact of VI, LNI, SDM, ESR and TS (p < 0.001), as well as mode of detection (p = 0.003) and ECOG PS (p = 0.002) on cancer specific survival. In multivariate analyses LNI was significantly associated with survival only in patients without SDM or VI (p < 0.001) with a hazard ratio of 9.0. LNI lost its prognostic significance when SDM or VI was present. Conclusion: Our findings underline the prognostic importance of the status of the lymph nodes. LNI, SDM, ESR, and VI were independently associated with cancer specific survival after radical nephrectomy. LNI provided the strongest prognostic information for patients without SDM or VI whereas SDM and VI had strongest impact on survival when there was no nodal involvement.en_US
dc.publisherBioMed Centraleng
dc.rightsAttribution CC BYeng
dc.titleThe prognostic relevance of interactions between venous invasion, lymph node involvement and distant metastases in renal cell carcinoma after radical nephrectomyen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2008 Zubac et al; licensee BioMed Central
dc.rights.holderZubac et al
dc.subject.nsiVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nefrologi, urologi: 772nob

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