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dc.contributor.authorAarhus, Madsen_US
dc.contributor.authorHelland, Christian Andreen_US
dc.contributor.authorLund-Johansen, Mortenen_US
dc.contributor.authorWester, Knuten_US
dc.contributor.authorKnappskog, Peren_US
dc.PublishedCerebrospinal Fluid Research 7:6en_US
dc.description.abstractBackground Intracranial arachnoid cysts (AC) are membranous sacs filled with CSF-like fluid that are commonly found in the temporal fossa. The majority of ACs are congenital. Typical symptoms are headache, dizziness, and dyscognition. Little is known about genes that contribute to the formation of the cyst membranes. Methods In order to identify differences in gene expression between normal arachnoid membrane (AM) and cyst membrane, we have performed a high-resolution mRNA microarray analysis. In addition we have screened DNA from AC samples for chromosomal duplications or deletions using DNA microarray-based copy number variation analysis. Results The transcriptome consisting of 33096 gene probes showed a near-complete similarity in expression between AC and AM samples. Only nine genes differed in expression between the two tissues: ASGR1, DPEP2, SOX9, SHROOM3, A2BP1, ATP10D, TRIML1, NMU were down regulated, whereas BEND5 was up regulated in the AC samples. Three of the AC samples had unreported human DNA copy number variations, all DNA gains. Conclusions Extending results of previous anatomical studies, the present study has identified a small subset of differentially expressed genes and DNA alterations in arachnoid cysts compared to normal arachnoid membrane.en_US
dc.publisherBioMed Centraleng
dc.rightsAttribution CC BYeng
dc.titleMicroarray-based gene expression profiling and DNA copy number variation analysis of temporal fossa arachnoid cystsen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderAarhus et al.
dc.rights.holderCopyright 2010 Aarhus et al; licensee BioMed Central Ltd.
dc.subject.nsiVDP::Medical disciplines: 700eng

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