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dc.contributor.authorStorli, Kristian E.en_US
dc.contributor.authorSøndenaa, Karlen_US
dc.contributor.authorBukholm, Ida Rashida Khanen_US
dc.contributor.authorNesvik, Idunnen_US
dc.contributor.authorBru, Toreen_US
dc.contributor.authorFurnes, Bjørgen_US
dc.contributor.authorHjelmeland, Bjarteen_US
dc.contributor.authorIversen, Knut B.en_US
dc.contributor.authorEide, Geir Egilen_US
dc.date.accessioned2011-11-21T10:08:23Z
dc.date.available2011-11-21T10:08:23Z
dc.date.issued2011-05-12eng
dc.PublishedInternational Journal of Colorectal Disease 26(10): 1299-1307en
dc.identifier.issn0179-1958
dc.identifier.urihttps://hdl.handle.net/1956/5202
dc.description.abstractBackground A national surveillance program of colon cancer treatment was introduced in 2007. We examined prognostic factors for colon cancer operated in 2000 with an aim of improving survival in the new program and a special focus on the merit of lymph node yield. Methods A cohort of 269 patients, 152 women (56.5%), with a mean age of 71 years, was operated for colon cancer in 2000 at three teaching hospitals and followed up for 7 years. Results Overall 5-year survival was 58.0%, and overall hospital mortality was 5.2%, with 4.5% in elective cases and 12.5% after urgent surgery. In only 41.1% of the specimens were 12 or more lymph nodes retrieved, but this did not affect survival in the combined cohort, although one of the hospitals achieved a significantly better result with a harvest of 12 or more lymph nodes. In a multivariate analysis, old age, gender, a high lymph node ratio (LNR) at stage III, and tumor–node–metastasis stage were adverse factors for survival. Conclusions The operative mortality was high and should be reassessed. The lymph node count did not have a significant impact on outcome overall, whereas the LNR proved significant for stage III. A prospective protocol using overall lymph node yield as a surrogate measure for more radical surgery, nevertheless, seems warranted to improve the lymph node harvest according to international recommendations.en_US
dc.language.isoengeng
dc.publisherSpringereng
dc.rights.urihttp://www.springer.com/open+access/open+choice?SGWID=0-40359-0-0-0eng
dc.subjectColon cancereng
dc.subjectLymph nodeseng
dc.subjectSurvivaleng
dc.titleOverall survival after resection for colon cancer in a national cohort study was adversely affected by TNM stage, lymph node ratio, gender, and old ageen_US
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersionen_US
dc.rights.holder©The Author(s) 2011
dc.identifier.doihttps://doi.org/10.1007/s00384-011-1244-2
dc.subject.nsiVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762eng


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