Vis enkel innførsel

dc.contributor.authorNæsgaard, Patrycja A.en_US
dc.contributor.authorFuente, Ricardo León de laen_US
dc.contributor.authorNilsen, Stein Toreen_US
dc.contributor.authorWoie, Leiken_US
dc.contributor.authorAarsland, Torbjørnen_US
dc.contributor.authorBrede, Catoen_US
dc.contributor.authorStaines, Harryen_US
dc.contributor.authorNilsen, Dennis W. T.en_US
dc.date.accessioned2013-04-11T09:16:10Z
dc.date.available2013-04-11T09:16:10Z
dc.date.issued2012-09-06eng
dc.PublishedPLoS ONE 7(9): e43228eng
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/1956/6503
dc.description.abstractBackground: Several studies have shown an association between vitamin D deficiency and cardiovascular risk. Vitamin D status is assessed by determination of 25-hydroxyvitamin D [25(OH)D] in serum. Methods: We assessed the prognostic utility of 25(OH)D in 982 chest-pain patients with suspected acute coronary syndrome (ACS) from Salta, Northern Argentina. 2-year follow-up data including all-cause mortality, cardiac death and sudden cardiac death were analyzed in quartiles of 25(OH)D, applying univariate and multivariate analysis. Results: There were statistically significant changes in seasonal 25(OH)D levels. At follow-up, 119 patients had died. The mean 25(OH)D levels were significantly lower among patients dying than in long-term survivors, both in the total population and in patients with a troponin T (TnT) release (n = 388). When comparing 25(OH)D in the highest quartile to the lowest quartile in a multivariable Cox regression model for all-cause mortality, the hazard ratio (HR) for cardiac death and sudden cardiac death in the total population was 0.37 (95% CI, 0.19–0.73), p = 0.004, 0.23 (95% CI, 0.08–0.67), p = 0.007, and 0.32 (95% CI, 0.11–0.94), p = 0.038, respectively. In patients with TnT release, the respective HR was 0.24 (95% CI, 0.10–0.54), p = 0.001, 0.18 (95% CI, 0.05–0.60), p = 0.006 and 0.25 (95% CI, 0.07–0.89), p = 0.033. 25(OH)D had no prognostic value in patients with no TnT release. Conclusion: Vitamin D was shown to be a useful biomarker for prediction of mortality when obtained at admission in chest pain patients with suspected ACS.en_US
dc.language.isoengeng
dc.publisherPublic Library of Scienceeng
dc.relation.ispartof<a href="http://hdl.handle.net/1956/6726" target="blank">Prognostic indicators of total-, cardiac- and sudden cardiac death in chest pain patients with suspected acute coronary syndrome (ACS).</a>eng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/2.5/eng
dc.titleSerum 25(OH)D Is a 2-Year Predictor of All-Cause Mortality, Cardiac Death and Sudden Cardiac Death in Chest Pain Patients from Northern Argentinaen_US
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright Næsgaard et al.
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0043228
dc.identifier.cristin943099


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Attribution CC BY
Med mindre annet er angitt, så er denne innførselen lisensiert som Attribution CC BY