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dc.contributor.authorGregersen, Kineen_US
dc.contributor.authorLind, Ragna Anneen_US
dc.contributor.authorBjørkkjær, Tormoden_US
dc.contributor.authorFrøyland, Livaren_US
dc.contributor.authorBerstad, Arnolden_US
dc.contributor.authorLied, Gülen Arslanen_US
dc.PublishedClinical medicine: Gastroenterology 1: 33-41eng
dc.description.abstractBackground: Food hypersensitivity is a prevalent condition with poorly characterized underlying mechanisms. In the present pilot study we investigated effects of seal oil and soy oil on meal-induced symptoms and gastric accommodation in patients with subjective food hypersensitivity (FH). Single dose experiment: On three consecutive days, 10 mL of seal oil, soy oil, or saline were randomly administered into the duodenum of 10 patients with subjective FH and 10 healthy volunteers through a nasoduodenal feeding tube 10–20 minutes before the ingestion of a test meal. Short-term treatment study: 24 patients with subjective FH were randomly allocated to 10 days’ treatment with either 10 mL of seal or soy oil, self-administrated through an indwelling nasoduodenal feeding tube, 3 times daily. In both experiments meal-induced abdominal symptoms and gastric accommodation were measured by visual analogue scales and external ultrasound respectively. Results: Symptoms and gastric accommodation were not significantly influenced by single doses of seal or soy oil. When given daily for 10 days, seal oil, but not soy oil, reduced total symptom scores significantly (P = 0.03). The symptomatic improvement was not associated with improvements in gastric accommodation. Conclusion: Daily administration of seal oil may benefit patients with subjective FH. The beneficial effect of seal oil in patients with subjective FH can not be ascribed to improved gastric accommodation.en_US
dc.publisherLibertas Academicaeng
dc.relation.ispartof<a href="" target="blank">Subjective food hypersensitivity</a>eng
dc.rightsAttribution-NonCommercial CC BY-NCeng
dc.titleEffects of Seal Oil on Meal-Induced Symptoms and Gastric Accommodation in Patients with Subjective Food Hypersensitivity: A Pilot Studyen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2008 Gregersen et al
dc.source.journalClinical medicine: Gastroenterology

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