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dc.contributor.authorLied, Gülen Arslanen_US
dc.contributor.authorVogelsang, Petraen_US
dc.contributor.authorBerstad, Arnolden_US
dc.contributor.authorAppel, Silkeen_US
dc.description.abstractSelf-reported hypersensitivity to food is a common condition and many of these patients have indications of intestinal immune activation. Dendritic cells (DCs) are recognized as the most potent antigen-presenting cells involved in both initiating immune responses and maintaining tolerance. The aims of this study were to evaluate the DC populations with their phenotype and T cell stimulatory capacity in patients with food hypersensitivity and to study its relationship with atopic disease. Blood samples from 10 patients with self-reported food hypersensitivity, divided into atopic and nonatopic subgroups, and 10 gender- and age-matched healthy controls were analyzed by flow cytometry using the Miltenyi Blood Dendritic cells kit. Monocyte-derived DCs (moDCs) were evaluated concerning their phenotype and T cell stimulatory capacity. DC populations and cell surface markers were not significantly different between patients and healthy controls, but moDCs from atopic patients expressed significantly more CD38 compared to moDCs from nonatopic patients. Moreover, lipopolysaccharide stimulated moDCs from atopic patients produced significantly more interleukin-10 compared to nonatopic patients. CD38 expression was correlated to total serum immunoglobulin E levels. These findings support the notion of immune activation in some patients with self-reported food hypersensitivity. They need to be confirmed in a larger cohort.en_US
dc.publisherDove Presseng
dc.rightsAttribution-NonCommercial CC BY-NCeng
dc.subjectFood hypersensitivityeng
dc.subjectDendritic cellseng
dc.titleDendritic cell populations in patients with self-reported food hypersensitivityen_US
dc.typePeer reviewed
dc.typeJournal article
dc.rights.holderCopyright 2011 Lied et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
dc.source.journalInternational Journal of General Medicine

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