Browsing Department of Clinical Science by Author "Ueland, Per Magne"

Now showing items 41-60 of 60

    • Maternal smoking impacts key biological pathways in newborns through epigenetic modification in Utero 

      Rotroff, Daniel M; Joubert, Bonnie R; Marvel, Skylar W; Håberg, Siri Eldevik; Wu, Michael C; Nilsen, Roy Miodini; Ueland, Per Magne; Nystad, Wenche; London, Stephanie J; Motsinger-Reif, Alison (Peer reviewed; Journal article, 2016-11-25)
      Background: Children exposed to maternal smoking during pregnancy exhibit increased risk for many adverse health effects. Maternal smoking influences methylation in newborns at specific CpG sites (CpGs). Here, we extend ...

    • Metabolic Profiling in Maturity-Onset Diabetes of the Young (MODY) and Young Onset Type 2 Diabetes Fails to Detect Robust Urinary Biomarkers 

      Gloyn, Anna L.; Faber, Johan H.; Malmodin, Daniel; Thanabalasingham, Gaya; Lam, Francis; Ueland, Per Magne (Peer reviewed; Journal article, 2012-07-30)
      It is important to identify patients with Maturity-onset diabetes of the young (MODY) as a molecular diagnosis determines both treatment and prognosis. Genetic testing is currently expensive and many patients are therefore ...

    • Microheterogeneity and preanalytical stability of protein biomarkers of inflammation and renal function 

      Gao, Jie; Ulvik, Arve; McCann, Adrian; Ueland, Per Magne; Meyer, Klaus (Journal article; Peer reviewed, 2021)
      Protein biomarker microheterogeneity has attracted increasing attention in epidemiological and clinical research studies. Knowledge concerning the preanalytical stability of proteins is paramount to assess the biological ...

    • Motor development related to duration of exclusive breastfeeding, B vitamin status and B12 supplementation in infants with a birth weight between 2000-3000 g, results from a randomized intervention trial 

      Torsvik, Ingrid Kristin; Ueland, Per Magne; Markestad, Trond; Midttun, Øivind; Monsen, Anne-Lise Bjørke (Peer reviewed; Journal article, 2015-12-18)
      Background: Exclusive breastfeeding for 6 months is assumed to ensure adequate micronutrients for term infants. Our objective was to investigate the effects of prolonged breastfeeding on B vitamin status and neurodevelopment ...

    • Parental smoking and risk of childhood-onset type 1 diabetes 

      Magnus, Maria Christine; Tapia, German; Olsen, Sjurdur Frodi; Granström, Charlotta; Mårild, Karl Staffan; Ueland, Per Magne; Midttun, Øivind; Svensson, Jannet; Johannesen, Jesper; Skrivarhaug, Torild; Joner, Geir; Njølstad, Pål Rasmus; Størdal, Ketil; Stene, Lars Christian Mørch (Peer reviewed; Journal article, 2018-11)
      Background: A few prospective studies suggest an association between maternal smoking during pregnancy and lower risk of type 1 diabetes. However, the role of unmeasured confounding and misclassification remains unclear. ...

    • Peroxisome Proliferator-Activated Receptor Activation is Associated with Altered Plasma One-Carbon Metabolites and B-Vitamin Status in Rats 

      Lysne, Vegard; Strand, Elin; Svingen, Gard Frodahl Tveitevåg; Bjørndal, Bodil; Pedersen, Eva Ringdal; Midttun, Øivind; Olsen, Thomas; Ueland, Per Magne; Berge, Rolf Kristian; Nygård, Ottar (Peer reviewed; Journal article, 2016-01-05)
      Plasma concentrations of metabolites along the choline oxidation pathway have been linked to increased risk of major lifestyle diseases, and peroxisome proliferator-activated receptors (PPARs) have been suggested to be ...

    • Plasma cystathionine and risk of incident stroke in patients with suspected stable angina pectoris 

      Dhar, Indu; Svingen, Gard Frodahl Tveitevåg; Ueland, Per Magne; Lysne, Vegard; Svenningsson, Mads Malm; Tell, Grethe S.; Nygård, Ottar (Peer reviewed; Journal article, 2018)
      Background: Cystathionine is an intermediate product in the transsulfuration pathway and formed during the B6‐dependent conversion of methionine to cysteine. Elevated plasma cystathionine has been related to atherosclerosis, ...

    • Plasma Glycine and Risk of Acute Myocardial Infarction in Patients With Suspected Stable Angina Pectoris 

      Ding, Yunpeng; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; Gregory, Jesse F.; Ueland, Per Magne; Tell, Grethe Seppola; Nygård, Ottar (Peer reviewed; Journal article, 2015)
      Background Glycine is an amino acid involved in antioxidative reactions, purine synthesis, and collagen formation. Several studies demonstrate inverse associations of glycine with obesity, hypertension, and diabetes mellitus. ...

    • Plasma methylmalonic acid predicts risk of acute myocardial infarction and mortality in patients with coronary heart disease: A prospective 2-cohort study 

      Dhar, Indu; Lysne, Vegard; Ulvik, Arve; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Kristine Ringdal; Bjørnestad, Espen Øglænd; Olsen, Thomas; Borsholm, Robert Andre; Laupsa-Borge, Johnny; Ueland, Per Magne; Tell, Grethe Seppola; Berge, Rolf Kristian; Mellgren, Gunnar; Bønaa, Kaare Harald; Nygård, Ottar Kjell (Journal article; Peer reviewed, 2023)
      Background Elevated plasma methylmalonic acid (MMA) is reported in patients with established coronary heart disease (CHD) and is considered a marker of vitamin B12 deficiency. Moreover, MMA-dependent reactions have been ...

    • Pre-diagnostic circulating concentrations of fat-soluble vitamins and risk of glioma in three cohort studies 

      Yue, Yiyang; Creed, Jordan H.; Cote, David J.; Stampfer, Meir J.; Wang, Molin; Midttun, Øivind; McCann, Adrian; Ueland, Per Magne; Furtado, Jeremy; Egan, Kathleen; Smith-Warner, Stephanie A. (Journal article; Peer reviewed, 2021)
      Few prospective studies have evaluated the relation between fat-soluble vitamins and glioma risk. Using three cohorts—UK Biobank (UKB), Nurses’ Health Study (NHS), and Health Professionals Follow-Up Study (HPFS), we ...

    • Prognostic impact of vitamin B6 metabolism in lung cancer 

      Galluzzi, Lorenzo; Vitale, Ilio; Senovilla, Laura; Olaussen, Ken André; Pinna, Guillaume; Eisenberg, Tobias; Goubar, Aïcha; Martins, Isabelle; Michels, Judith; Kratassiouk, Guerorgui; Carmona-Gutierrez, Didac; Scoazec, Marie; Vacchelli, Erika; Schlemmer, Frederic; Kepp, Oliver; Shen, Sheshi; Tailler, Maximilien; Niso-Santano, Mireia; Morselli, Eugenia; Criollo, Alfredo; Adjemian, Sandy; Jemaa, Mohamed; Chaba, Kariman; Pailleret, Claire; Michaud, Mickaël; Pietrocola, Federico; Tajeddine, Nicolas; Rouge, Thibault de La Motte; Araujo, Natalia; Morozova, Nadya; Robert, Thomas; Ripoche, Hugues; Commo, Frederic; Besse, Benjamin; Validire, Pierre; Fouret, Pierre; Robin, Angélique; Dorvault, Nicolas; Girard, Philippe; Gouy, Sébastien; Pautier, Patricia; Jägemann, Nora; Nickel, Ann-Christin; Marsili, Sabrina; Paccard, Caroline; Servant, Nicolas; Hupé, Philippe; Behrens, Carmen; Behnam-Motlagh, Paviz; Kohno, Kimitoshi; Cremer, Isabelle; Damotte, Diane; Alifano, Marco; Midttun, Øivind; Ueland, Per Magne; Lazar, Vladimir; Dessen, Philippe; Zischka, Hans; Chatelut, Etienne; Castedo, Maria; Madeo, Frank; Barillot, Emmanuel; Thomale, Jürgen; Wistuba, Ignacio Ivan; Sautes-Fridman, Catherine; Zitvogel, Laurence; Soria, Jean-Charles; Harel-Bellan, Annick; Kroemer, Guido (Peer reviewed; Journal article, 2012-08-30)
      Patients with non-small cell lung cancer (NSCLC) are routinely treated with cytotoxic agents such as cisplatin. Through a genome-wide siRNA-based screen, we identified vitamin B6 metabolism as a central regulator of cisplatin ...

    • Short-term treatment with a peroxisome proliferator-activated receptor α agonist influences plasma one-carbon metabolites and B-vitamin status in rats 

      Lysne, Vegard; Bjørndal, Bodil; Grinna, Mari Lausund; Midttun, Øivind; Ueland, Per Magne; Berge, Rolf Kristian; Dierkes, Jutta; Nygård, Ottar; Strand, Elin (Peer reviewed; Journal article, 2019-12-05)
      Introduction: Peroxisome proliferator-activated receptors (PPARs) have been suggested to be involved in the regulation of one-carbon metabolism. Previously we have reported effects on plasma concentrations of metabolites ...

    • Transsulfuration metabolites and the association with incident atrial fibrillation – An observational cohort study among Norwegian patients with stable angina pectoris 

      Svenningsson, Mads Malm; Svingen, Gard Frodahl Tveitevåg; Lysne, Vegard; Ueland, Per Magne; Tell, Grethe S.; Pedersen, Eva Ringdal; Dhar, Indu; Nilsen, Dennis W.T.; Nygård, Ottar (Journal article; Peer reviewed, 2020)
      Background/aim Plasma total homocysteine (tHcy) is elevated in patients with persistent vs. paroxysmal atrial fibrillation (AF), and has been related to increased risk of new-onset AF. Homocysteine is degraded to cystathionine ...

    • Trimethyllysine predicts all-cause and cardiovascular mortality in community-dwelling adults and patients with coronary heart disease 

      Bjørnestad, Espen Øglænd; Dhar, Indu; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Kristine Ringdal; Svenningsson, Mads Malm; Tell, Grethe Seppola; Ueland, Per Magne; Ørn, Stein; Sulo, Gerhard; Laaksonen, Reijo; Nygård, Ottar Kjell (Journal article; Peer reviewed, 2021)
      Aims Trimethyllysine (TML) is involved in carnitine synthesis, serves as a precursor of trimethylamine N-oxide (TMAO) and is associated with cardiovascular events in patients with established coronary heart disease (CHD). ...

    • Tryptophan catabolites as metabolic markers of vitamin B-6 status evaluated in cohorts of healthy adults and cardiovascular patients 

      Ulvik, Arve; Midttun, Øivind; McCann, Adrian; Meyer, Klaus; Tell, Grethe S.; Nygård, Ottar; Ueland, Per Magne (Journal article; Peer reviewed, 2020)
      Background Vitamin B-6 status is routinely measured as pyridoxal 5′-phosphate (PLP) in plasma. Low concentrations of PLP are associated with rheumatic, cardiovascular, and neoplastic diseases. We have previously shown ...

    • Urinary excretion of homocysteine thiolactone and the risk of acute myocardial infarction in coronary artery disease patients: the WENBIT trial 

      Borowczyk, Kamila; Piechocka, Justyna; Głowacki, Rafał; Dhar, Indu; Midttun, Øivind; Tell, Grethe S.; Ueland, Per Magne; Nygård, Ottar; Jakubowski, Hieronim (Peer reviewed; Journal article, 2018)
      Objectives: No individual homocysteine (Hcy) metabolite has been studied as a risk marker for coronary artery disease (CAD). Our objective was to examine Hcy‐thiolactone, a chemically reactive metabolite generated by ...

    • Using metabolic profiling and gene expression analyses to explore molecular effects of replacing saturated fat with polyunsaturated fat-a randomized controlled dietary intervention study 

      Ulven, Stine Marie; Christensen, Jacob J.; Nygård, Ottar; Svardal, Asbjørn M.; Leder, Lena; Ottestad, Inger; Lysne, Vegard; Laupsa-Borge, Johnny; Ueland, Per Magne; Midttun, Øivind; Meyer, Klaus; McCann, Adrian; Andersen, Lene Frost; Holven, Kirsten Bjørklund (Peer reviewed; Journal article, 2019-04-26)
      Background: Replacing dietary saturated fatty acids (SFAs) with polyunsaturated fatty acids (PUFA) reduces the plasma low-density lipoprotein (LDL) cholesterol and subsequently the risk of cardiovascular disease. However, ...

    • Vegan diet and bone health—results from the cross-sectional RBVD study 

      Menzel, Juliane; Abraham, Klaus; Stangl, Gabriele I.; Ueland, Per Magne; Obeid, Rima; Schulze, Matthias B.; Herter-Aeberli, Isabelle; Schwerdtle, Tanja; Weikert, Cornelia (Journal article; Peer reviewed, 2021)
      Scientific evidence suggests that a vegan diet might be associated with impaired bone health. Therefore, a cross-sectional study (n = 36 vegans, n = 36 omnivores) was used to investigate the associations of veganism with ...

    • Within-person reproducibility of proteoforms related to inflammation and renal dysfunction 

      Gao, Jie; McCann, Adrian; Laupsa-Borge, Johnny; Nygård, Ottar Kjell; Ueland, Per Magne; Meyer, Klaus (Journal article; Peer reviewed, 2022)
      Protein biomarkers and microheterogeneity have attracted increasing attention in epidemiological and clinical research. Knowledge of within-person reproducibility over time is paramount to determine whether a single ...

    • β-blocker use and risk of all-cause mortality in patients with coronary heart disease: effect modification by serum vitamin A 

      Dhar, Indu; Svingen, Gard Frodahl Tveitevåg; Olsen, Thomas; Lysne, Vegard; Bjørnestad, Espen Øglænd; Ueland, Per Magne; Nygård, Ottar Kjell (Journal article; Peer reviewed, 2021)
      Aims  Blockade of β-adrenoceptors reduces sympathetic nervous system activity and improves survival in patients with heart failure with reduced left ventricular ejection fraction (HFrEF); however, any improvement in ...