Browsing Department of Clinical Science by Author "Kadiwala, Juned"

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HNF4A haploinsufficiency in MODY1 abrogates liver and pancreas differentiation from patient-derived induced pluripotent stem cells

Ng, Natasha Hui Jin; Jasmen, Joanita Binte; Lim, Chang Siang; Lau, Hwee Hui; Krishnan, Vidhya Gomathi; Kadiwala, Juned; Kulkarni, Rohit N.; Ræder, Helge; Vallier, Ludovic; Hoon, Shawn; Teo, Adrian Kee Keong (Peer reviewed; Journal article, 2019-06-28)

Maturity-onset diabetes of the young 1 (MODY1) is a monogenic diabetes condition caused by heterozygous HNF4A mutations. We investigate how HNF4A haploinsufficiency from a MODY1/HNF4A mutation influences the development ...