Blar i Department of Clinical Science på forfatter "Tangedal, Solveig"
-
Comparing microbiota profiles in induced and spontaneous sputum samples in COPD patients
Tangedal, Solveig; Aanerud, Marianne; Grønseth, Rune; Drengenes, Christine; Wiker, Harald G; Bakke, Per S.; Eagan, Tomas Mikal (Peer reviewed; Journal article, 2017-08-29)Background: Induced and spontaneous sputum are used to evaluate the airways microbiota. Whether the sputum types can be used interchangeably in microbiota research is unknown. Our aim was to compare microbiota in induced ... -
Comparison of inflammatory markers in induced and spontaneous sputum in a cohort of COPD patients
Tangedal, Solveig; Aanerud, Marianne; Persson, Louise Jeanette Pauline; Brokstad, Karl Albert; Bakke, Per S.; Eagan, Tomas Mikal (Peer reviewed; Journal article, 2014-11-15)Background: Sputum induction is a non-invasive method for obtaining measurements of inflammation in the airways. Whether spontaneously sampled sputum can be a valid surrogate is unknown. The aim of this study was to compare ... -
A longitudinal study of the pulmonary mycobiome in subjects with and without chronic obstructive pulmonary disease
Martinsen, Einar Marius Hjellestad; Eagan, Tomas Mikal Lind; Wiker, Harald Gotten; Leiten, Elise Orvedal; Husebø, Gunnar Reksten; Knudsen, Kristel Svalland; Tangedal, Solveig; Sanseverino, Walter; Paytuví-Gallart, Andreu; Nielsen, Rune (Journal article; Peer reviewed, 2022-05-12)Background: Few studies have examined the stability of the pulmonary mycobiome. We report longitudinal changes in the oral and pulmonary mycobiome of participants with and without COPD in a large-scale bronchoscopy study ... -
The lower airway microbiota and inflammation in chronic obstructive pulmonary disease (COPD) : Thoughts on where to measure it, how to interpret it, and why it might matter
Tangedal, Solveig (Doctoral thesis, 2024-02-01)Bakgrunn: Kronisk obstruktiv lungesjukdom (KOLS) er ein kompleks, inflammatorisk sjukdom som forårsakar millionar av dødsfall årleg. Bakteriane i dei nedre luftvegane (mikrobiotaet) og immunresponsar kan spele ei viktig ... -
The lower airways microbiome and antimicrobial peptides in idiopathic pulmonary fibrosis differ from chronic obstructive pulmonary disease
Knudsen, Kristel Svalland; Lehmann, Sverre; Nielsen, Rune; Tangedal, Solveig; Haaland, Ingvild; Hiemstra, Pieter S.; Eagan, Tomas Mikal Lind (Journal article; Peer reviewed, 2022)Background The lower airways microbiome and host immune response in chronic pulmonary diseases are incompletely understood. We aimed to investigate possible microbiome characteristics and key antimicrobial peptides and ... -
The lower airways microbiota and antimicrobial peptides indicate dysbiosis in sarcoidosis
Knudsen, Kristel Svalland; Lehmann, Sverre; Nielsen, Rune; Tangedal, Solveig; Paytuví-Gallart, Andreu; Sanseverino, Walter; Martinsen, Einar Marius Hjellestad; Hiemstra, Pieter S.; Eagan, Tomas Mikal Lind (Journal article; Peer reviewed, 2022-10-19)Background: The role of the pulmonary microbiome in sarcoidosis is unknown. The objectives of this study were the following: (1) examine whether the pulmonary fungal and bacterial microbiota differed in patients with ... -
Protected sampling is preferable in bronchoscopic studies of the airway microbiome
Grønseth, Rune; Drengenes, Christine; Wiker, Harald G; Tangedal, Solveig; Xue, Yaxin; Husebø, Gunnar; Svanes, Øistein; Lehmann, Sverre; Aardal, Marit Elisabeth; Hoang, Tuyen; Kalananthan, Tharmini; Martinsen, Einar Marius Hjellestad; Leiten, Elise Orvedal; Aanerud, Marianne; Nordeide, Eli; Haaland, Ingvild; Jonassen, Inge; Bakke, Per S.; Eagan, Tomas Mikal (Journal article; Peer reviewed, 2017)The aim was to evaluate susceptibility of oropharyngeal contamination with various bronchoscopic sampling techniques. 67 patients with obstructive lung disease and 58 control subjects underwent bronchoscopy with ... -
Sputum microbiota and inflammation at stable state and during exacerbations in a cohort of chronic obstructive pulmonary disease (COPD) patients
Tangedal, Solveig; Nielsen, Rune; Aanerud, Marianne; Persson, Louise Jeanette Pauline; Wiker, Harald G; Bakke, Per S.; Hiemstra, Pieter S.; Eagan, Tomas Mikal (Peer reviewed; Journal article, 2019-09-17)Background: Exacerbations of chronic obstructive pulmonary disease (COPD) are debilitating events and spur disease progression. Infectious causes are frequent; however, it is unknown to what extent exacerbations are caused ...