Blar i Department of Clinical Science på tidsskrift "Frontiers in Endocrinology"

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    • Autoimmune primary adrenal insufficiency -current diagnostic approaches and future perspectives 

      Wolff, Anette Susanne Bøe; Kucuka, Isil; Oftedal, Bergithe Eikeland (Journal article; Peer reviewed, 2023)
      The adrenal glands are small endocrine glands located on top of each kidney, producing hormones regulating important functions in our body like metabolism and stress. There are several underlying causes for adrenal ...

    • Coexistence of Congenital Adrenal Hyperplasia and Autoimmune Addison's Disease 

      Aslaksen, Sigrid; Methlie, Paal; Vigeland, Magnus Dehli; Jøssang, Dag Eirik; Wolff, Anette Susanne Bøe; Sheng, Ying; Oftedal, Bergithe Eikeland; Skinningsrud, Beate; Undlien, Dag Erik; Selmer, Kaja Kristine; Husebye, Eystein Sverre; Bratland, Eirik (Peer reviewed; Journal article, 2019-09-27)
      Background: Underlying causes of adrenal insufficiency include congenital adrenal hyperplasia (CAH) and autoimmune adrenocortical destruction leading to autoimmune Addison's disease (AAD). Here, we report a patient with a ...

    • The effect of WnT pathway modulators on human iPSC-derived pancreatic beta cell maturation 

      Vethe, Heidrun; Ghila, Luiza; Berle, Magnus; Hoareau, Laurence; Haaland, Øystein Ariansen; Scholz, Hanne; Paulo, Joao A.; Chera, Simona; Ræder, Helge (Peer reviewed; Journal article, 2019-05-08)
      Current published protocols for targeted differentiation of human stem cells toward pancreatic β-cells fail to deliver sufficiently mature cells with functional properties comparable to human islet β-cells. We aimed to ...

    • Increased Plasma Soluble Interleukin-2 Receptor Alpha Levels in Patients With Long-Term Type 1 Diabetes With Vascular Complications Associated With IL2RA and PTPN2 Gene Polymorphisms 

      Keindl, Magdalena; Fedotkina, Olena; du Plessis, Elsa; Jain, Ruchi; Bergum, Brith; Mygind Jensen, Troels; Laustrup Møller, Cathrine; Falhammar, Henrik; Nyström, Thomas; Catrina, Sergiu-Bogdan; Jörneskog, Gun; Groop, Leif; Eliasson, Mats; Eliasson, Björn; Brismar, Kerstin; Nilsson, Peter M.; Berg, Tore Julsrud; Appel, Silke; Lyssenko, Valeriya (Journal article; Peer reviewed, 2020)
      Type 1 diabetes (T1D) is largely considered an autoimmune disease leading to the destruction of insulin-producing pancreatic β cells. Further, patients with T1D have 3–4-fold increased risk of developing micro- and ...

    • Metabolic and Epigenetic Regulation by Estrogen in Adipocytes 

      Bjune, Jan-Inge; Strømland, Pouda Panahandeh; Jersin, Regine Åsen; Mellgren, Gunnar; Dankel, Simon N (Journal article; Peer reviewed, 2022-02-22)
      Sex hormones contribute to differences between males and females in body fat distribution and associated disease risk. Higher concentrations of estrogens are associated with a more gynoid body shape and with more fat storage ...

    • Modulating Wnt signaling in human induced pluripotent stem cell-derived S7 cells 

      Vethe, Heidrun; Ghila, Luiza; Berle, Magnus; Hoareau, Laurence; Haaland, Øystein Ariansen; Scholz, Hanne; Paulo, Joao A.; Chera, Simona; Ræder, Helge (Peer reviewed; Journal article, 2019)
      Current published protocols for targeted differentiation of human stem cells toward pancreatic β-cells fail to deliver sufficiently mature cells with functional properties comparable to human islet β-cells. We aimed to ...

    • Multi-omics and machine learning for the prevention and management of female reproductive health 

      Kharb, Simmi; Joshi, Anagha (Journal article; Peer reviewed, 2023)
      Females typically carry most of the burden of reproduction in mammals. In humans, this burden is exacerbated further, as the evolutionary advantage of a large and complex human brain came at a great cost of women’s ...

    • Peripheral and central macrophages in obesity 

      Mukherjee, Sayani; Skrede, Silje; Haugstøyl, Martha; López, Miguel; Fernø, Johan (Journal article; Peer reviewed, 2023)
      Obesity is associated with chronic, low-grade inflammation. Excessive nutrient intake causes adipose tissue expansion, which may in turn cause cellular stress that triggers infiltration of pro-inflammatory immune cells ...

    • Sex-Specific Limitations in Physical Health in Primary Adrenal Insufficiency 

      Didriksen, Nora Møller; Sævik, Åse Bjorvatn; Sortland, Linn Solveig; Øksnes, Marianne; Husebye, Eystein Sverre (Journal article; Peer reviewed, 2021)
      Background: Patients with primary adrenal insufficiency (PAI) suffer reduced quality of life (QoL), but comparisons with large-scale normative data are scarce. The clinical characteristics associated with reduced QoL are ...

    • Subtype-specific surface proteins on adipose tissue macrophages and their association to obesity-induced insulin resistance 

      Strand, Kristina; Stiglund, Natalie; Haugstøyl, Martha Eimstad; Kamyab, Seyedeh Zahra; Langhelle, Victoria Puntervold; Dyer, Laurence; Busch, Christian; Cornillet, Martin; Hjellestad, Iren Drange; Nielsen, Hans Jørgen; Njølstad, Pål Rasmus; Mellgren, Gunnar; Björkström, Niklas K.; Fernø, Johan (Journal article; Peer reviewed, 2022)
      A chronic low-grade inflammation, originating in the adipose tissue, is considered a driver of obesity-associated insulin resistance. Macrophage composition in white adipose tissue is believed to contribute to the pathogenesis ...