Department of Clinical Science: Recent submissions

Now showing items 21-40 of 2607

    • Barriers and enablers to medicine-taking behaviours in chronic obstructive pulmonary disease: a qualitative interview study 

      Nygård, Torbjørn; Wright, David; Kjome, Reidun Lisbet Skeide; Nazar, Hamde; Aarli, Bernt Bøgvald; Raddum, Aase Merethe (Journal article; Peer reviewed, 2025)
      Background: Chronic Obstructive Pulmonary Disease (COPD) is associated with low health-related quality of life and high costs to healthcare systems, particularly due to hospital admissions and exacerbations. Medicines, ...

    • Development of a medicines-support intervention for people with chronic obstructive pulmonary disease : Exploring patient needs, contexts, and behavioural factors 

      Nygård, Torbjørn (Doctoral thesis, 2025-04-11)
      Bakgrunn: Legemidler er grunnleggende i behandlingen av kronisk obstruktiv lungesykdom (kols), både for symptomreduksjon og i forebygging og behandling av kols-forverringer. Helsepersonell, inkludert apotekfarmasøyter, kan ...

    • Understanding the genetic complexity of puberty timing across the allele frequency spectrum 

      Kentistou, Katherine A.; Kaisinger, Lena R.; Stankovic, Stasa; Vaudel, Marc; Mendes de Oliveira, Edson; Messina, Andrea; Walters, Robin G.; Liu, Xiaoxi; Busch, Alexander S.; Helgason, Hannes; Thompson, Deborah J.; Santoni, Federico; Petricek, Konstantin M.; Zouaghi, Yassine; Huang-Doran, Isabel; Gudbjartsson, Daniel F.; Bratland, Eirik; Lin, Kuang; Gardner, Eugene J.; Zhao, Yajie; Jia, Raina Y.; Terao, Chikashi; Riggan, Marjorie J.; Bolla, Manjeet K.; Yazdanpanah, Mojgan; Yazdanpanah, Nahid; Bradfield, Jonathan P.; Broer, Linda; Campbell, Archie; Chasman, Daniel I.; Cousminer, Diana L.; Franceschini, Nora; Franke, Lude H.; Girotto, Giorgia; He, Chunyan; Järvelin, Marjo-Riitta; Joshi, Peter K.; Kamatani, Yoichiro; Karlsson, Robert; Luan, Jian’an; Lunetta, Kathryn L.; Mägi, Reedik; Mangino, Massimo; Medland, Sarah E.; Meisinger, Christa; Noordam, Raymond; Nutile, Teresa; Concas, Maria Pina; Polašek, Ozren; Porcu, Eleonora; Ring, Susan M.; Sala, Cinzia; Smith, Albert V.; Tanaka, Toshiko; van der Most, Peter J.; Vitart, Veronique; Wang, Carol A.; Willemsen, Gonneke; Zygmunt, Marek; Ahearn, Thomas U.; Andrulis, Irene L.; Anton-Culver, Hoda; Antoniou, Antonis C.; Auer, Paul L.; Barnes, Catriona L. K.; Beckmann, Matthias W.; Berrington de Gonzalez, Amy; Bogdanova, Natalia V.; Bojesen, Stig E.; Brenner, Hermann; Buring, Julie E.; Canzian, Federico; Chang-Claude, Jenny; Couch, Fergus J.; Cox, Angela; Crisponi, Laura; Czene, Kamila; Daly, Mary B.; Demerath, Ellen W.; Dennis, Joe; Devilee, Peter; De Vivo, Immaculata; Dörk, Thilo; Dunning, Alison M.; Dwek, Miriam; Eriksson, Johan G.; Fasching, Peter A.; Fernandez-Rhodes, Lindsay; Ferreli, Liana; Fletcher, Olivia; Gago-Dominguez, Manuela; García-Closas, Montserrat; García-Sáenz, José A.; González-Neira, Anna; Grallert, Harald; Guénel, Pascal; Haiman, Christopher A.; Hall, Per; Hamann, Ute; Hakonarson, Hakon; Hart, Roger J.; Hickey, Martha; Hooning, Maartje J.; Hoppe, Reiner; Hopper, John L.; Hottenga, Jouke-Jan; Hu, Frank B.; Huebner, Hanna; Hunter, David J.; Jernström, Helena; John, Esther M.; Karasik, David; Khusnutdinova, Elza K.; Kristensen, Vessela N.; Lacey, James V.; Lambrechts, Diether; Launer, Lenore J.; Lind, Penelope A.; Lindblom, Annika; Magnusson, Patrik K. E.; Mannermaa, Arto; McCarthy, Mark I.; Meitinger, Thomas; Menni, Cristina; Michailidou, Kyriaki; Millwood, Iona Y.; Milne, Roger L.; Montgomery, Grant W.; Nevanlinna, Heli; Nolte, Ilja M.; Nyholt, Dale R.; Obi, Nadia; O’Brien, Katie M.; Offit, Kenneth; Oldehinkel, Albertine J.; Ostrowski, Sisse R.; Palotie, Aarno; Pedersen, Ole B.; Peters, Annette; Pianigiani, Giulia; Plaseska-Karanfilska, Dijana; Pouta, Anneli; Pozarickij, Alfred; Radice, Paolo; Rennert, Gad; Rosendaal, Frits Richard; Ruggiero, Daniela; Saloustros, Emmanouil; Sandler, Dale P.; Schipf, Sabine; Schmidt, Carsten O.; Schmidt, Marjanka K.; Small, Kerrin; Spedicati, Beatrice; Stampfer, Meir; Stone, Jennifer; Tamimi, Rulla M.; Teras, Lauren R.; Tikkanen, Emmi; Turman, Constance; Vachon, Celine M.; Wang, Qin; Winqvist, Robert; Wolk, Alicja; Zemel, Babette S.; Zheng, Wei; van Dijk, Ko W.; Alizadeh, Behrooz Z.; Bandinelli, Stefania; Boerwinkle, Eric; Boomsma, Dorret I.; Ciullo, Marina; Chenevix-Trench, Georgia; Cucca, Francesco; Esko, Tõnu; Gieger, Christian; Grant, Struan F. A.; Gudnason, Vilmundur; Hayward, Caroline; Kolčić, Ivana; Kraft, Peter; Lawlor, Deborah A.; Martin, Nicholas G.; Nøhr, Ellen Aagaard; Pedersen, Nancy L.; Pennell, Craig E.; Ridker, Paul M.; Robino, Antonietta; Snieder, Harold; Sovio, Ulla; Spector, Tim D.; Stöckl, Doris; Sudlow, Cathie; Timpson, Nic J.; Toniolo, Daniela; Uitterlinden, André; Ulivi, Sheila; Völzke, Henry; Wareham, Nicholas J.; Widen, Elisabeth; Wilson, James F.; Pharoah, Paul D. P.; Li, Liming; Easton, Douglas F.; Njølstad, Pål Rasmus; Sulem, Patrick; Murabito, Joanne M.; Murray, Anna; Manousaki, Despoina; Juul, Anders; Erikstrup, Christian; Stefansson, Kari; Horikoshi, Momoko; Chen, Zhengming; Farooqi, I. Sadaf; Pitteloud, Nelly; Johansson, Stefan; Day, Felix R.; Perry, John R. B.; Ong, Ken K.; John, Esther M.; Hall, Per; Winqvis, Robert (Journal article; Peer reviewed, 2024)
      Pubertal timing varies considerably and is associated with later health outcomes. We performed multi-ancestry genetic analyses on ~800,000 women, identifying 1,080 signals for age at menarche. Collectively, these explained ...

    • Deletion of exchange proteins directly activated by cAMP (Epac) causes defects in hippocampal signaling in female mice 

      Aesoy, Reidun; Muwonge, Haruna; Sivertsen Åsrud, Kathrine; Sabir, Misbah; Witsø, Solveig Lund; Bjørnstad, Ronja; Kopperud, Reidun Kristin; Høivik, Erling Andre; Doskeland, Stein Ove; Bakke, Marit (Journal article; Peer reviewed, 2018-07-26)
      Previous studies demonstrate essential roles for the exchange proteins directly activated by cAMP 1 and 2 (Epac1 and Epac2; here collectively referred to as Epac) in the brain. In the hippocampus, Epac contributes to the ...

    • Diagnostic Stewardship in Community-Acquired Pneumonia with Syndromic Molecular Testing: A Randomized Clinical Trial 

      Markussen, Dagfinn Lunde; Serigstad, Sondre; Ritz, Christian; Knoop, Siri Tandberg; Ebbesen, Marit Helen; Faurholt-Jepsen, Daniel; Heggelund, Lars; Van Werkhoven, Cornelis H.; Clark, Tristan W.; Bjørneklett, Rune Oskar; Kommedal, Øyvind; Ulvestad, Elling; Grewal, Harleen (Journal article; Peer reviewed, 2024)
      Importance Lower respiratory tract (LRT) infections, including community-acquired pneumonia (CAP), are a leading cause of hospital admissions and mortality. Molecular tests have the potential to optimize treatment decisions ...

    • A rapid deployment valve option for failing Medtronic Freestyle full root: a single centre experience 

      Kolseth, Solveig Moss; Saeed, Sahrai; Salminen, Pirjo-Riitta; Ellensen, Vegard Skalstad; Kvalheim, Venny Lise; Mohamed Ali, Abukar; Haaverstad, Rune (Journal article; Peer reviewed, 2024)
      Background There are several high-risk treatment options for valve failure of a biological full root replacement. When tailoring the best treatment option for the patient, implantation of a rapid deployment valve (RDV) ...

    • Microbial aetiology of community-acquired pneumonia in hospitalised adults: A prospective study utilising comprehensive molecular testing 

      Markussen, Dagfinn Lunde; Kommedal, Øyvind; Knoop, Siri Tandberg; Ebbesen, Marit Helen; Bjørneklett, Rune Oskar; Ritz, Christian; Heggelund, Lars; Ulvestad, Elling; Serigstad, Sondre; Grewal, Harleen (Journal article; Peer reviewed, 2024)
      Objectives This study aimed to describe the microbial aetiology of community-acquired pneumonia (CAP) in adults admitted to a tertiary care hospital and assess the impact of syndromic polymerase chain reaction (PCR) panels ...

    • Loss of vimentin expression in preoperative biopsies independently predicts poor prognosis, lymph node metastasis and recurrence in endometrial cancer 

      Hjelmeland, Marta Espevold; Lien, Hilde Eide; Berg, Hege Fredriksen; Woie, Kathrine; Werner, Henrica Maria Johanna; Amant, Frederic; Haldorsen, Ingfrid Helene Salvesen; Trovik, Jone; Krakstad, Camilla (Journal article; Peer reviewed, 2024)
      Background: Precise preoperative risk classification of endometrial cancer is crucial for treatment decisions. Existing clinical markers often fail to accurately predict lymph node metastasis and recurrence risk. Loss of ...

    • Precision prognostics for cardiovascular disease in Type 2 diabetes: a systematic review and meta-analysis 

      Ahmad, Abrar; Lim, Lee-Ling; Morieri, Mario Luca; Tam, Claudia Ha-ting; Cheng, Feifei; Chikowore, Tinashe; Dudenhöffer-Pfeifer, Monika; Fitipaldi, Hugo; Huang, Chuiguo; Kanbour, Sarah; Sarkar, Sudipa; Koivula, Robert Wilhelm; Motala, Ayesha A.; Tye, Sok Cin; Yu, Gechang; Zhang, Yingchai; Provenzano, Michele; Sherifali, Diana; de Souza, Russell J.; Tobias, Deirdre Kay; Franks, Paul W.; Rich, Stephen S.; Wagner, Robert; Vilsbøll, Tina; Vesco, Kimberly K.; Udler, Miriam S.; Tuomi, Tiinamaija; Sweeting, Arianne; Sims, Emily K.; Sherr, Jennifer L.; Semple, Robert K.; Reynolds, Rebecca M.; Redondo, Maria J.; Redman, Leanne M.; Pratley, Richard E.; Pop-Busui, Rodica; Pollin, Toni I.; Perng, Wei; Pearson, Ewan R.; Ozanne, Susan E.; Owen, Katharine R.; Oram, Richard; Murphy, Rinki; Mohan, Viswanathan; Misra, Shivani; Meigs, James B.; Mathioudakis, Nestoras; Mathieu, Chantal; Ma, Ronald C. W.; Loos, Ruth J. F.; Lim, Siew S.; Laffel, Lori M.; Kwak, Soo Heon; Josefson, Jami L.; Hood, Korey K.; Hivert, Marie-France; Hirsch, Irl B.; Hattersley, Andrew T.; Griffin, Kurt; Greeley, Siri Atma W.; Gottlieb, Peter A.; Gloyn, Anna L.; Florez, Jose C.; Dennis, John M.; Costacou, Tina; Boyle, Kristen; Billings, Liana K.; Brown, Rebecca J.; Philipson, Louis H.; Nolan, John J.; Eckel, Robert H.; Mixter, Emily; Mekonnen, Eskedar Getie; Gruber, Chandra; Fawcett, Andrea J.; de Souza, Russell; Auh, Sungyoung; Zhu, Yeyi; Zhang, Cuilin; Saint-Martin, Cécile; Pomares-Millan, Hugo; Njølstad, Pål Rasmus; Nakabuye, Mariam; Molnes, Janne; McGovern, Andrew; Maloney, Kristin A.; Flanagan, Sarah E.; de Franco, Elisa; Aukrust, Ingvild; Polak, Michel; Beltrand, Jacques; Zhou, Shao J.; White, Sara L.; Hannah, Wesley; Wentworth, John M.; Vatier, Camille; Van der Schueren, Bart; Urazbayeva, Marzhan; Ukke, Gebresilasea Gendisha; Taylor, Rachael; Støy, Julie; Stefan, Norbert; Steck, Andrea K.; Steenackers, Nele; Stanislawski, Maggie A.; Speake, Cate; Sheu, Wayne Huey-Herng; Selvin, Elizabeth; Scholtens, Denise M.; Monaco, Gabriela S. F.; Santhakumar, Vanessa; Saeed, Zeb; Ried-Larsen, Mathias; Ray, Debashree; Jain, Rashmi; Quinteros, Alejandra; Powe, Camille E.; Petrie, John R.; Perez, Dianna; Pazmino, Sofia; Pathirana, Maleesa; Pankow, James S.; Onengut-Gumuscu, Suna; Morton, Robert W.; Lowe, William L.; Long, S. Alice; Liu, Kai; Libman, Ingrid M.; Leung, Gloria K. W.; Leong, Aaron; Koivula, Robert W.; Jones, Angus G.; Johnson, Randi K.; Hoag, Benjamin; Ismail, Heba M.; Harris-Kawano, Arianna; Hansen, Torben; Habibi, Nahal; Guasch-Ferré, Marta; Grieger, Jessica A.; Goodarzi, Mark O.; Gitelman, Stephen E.; Fitzpatrick, Stephanie L.; Fernández-Balsells, María Mercè; Evans-Molina, Carmella; DiMeglio, Linda A.; Dickens, Laura T.; Deutsch, Aaron J.; Dawed, Adem Y.; Dabelea, Dana; Clemmensen, Christoffer; Chivers, Sian C.; Chen, Mingling; Bonham, Maxine P.; Andersen, Mette K.; Amouyal, Chloé; Young, Katherine; Yamamoto, Jennifer M.; Wong, Jessie J.; Wang, Caroline C.; Wallace, Amelia S.; Tosur, Mustafa; Thuesen, Anne Cathrine B.; Takele, Wubet Worku; Svalastoga, Pernille; Sevilla-Gonzalez, Magdalena; Semnani-Azad, Zhila; Schön, Martin; Rooney, Mary R.; Raghavan, Sridharan; Prystupa, Katsiaryna; Pilla, Scott J.; Patel, Kashyap Amratlal; Ozkan, Bige; Naylor, Rochelle N.; Most, Jasper; Miller, Rachel G.; Mclennan, Niamh-Maire; Massey, Robert; Männistö, Jonna M. E.; Lim, Lee-Ling; Kreienkamp, Raymond J.; Kettunen, Jarno L. T.; Kahkoska, Anna R.; Jacobsen, Laura M.; Ikle, Jennifer M.; Hughes, Alice; Haider, Eram; Gaillard, Romy; Gingras, Véronique; Gillard, Pieter; Francis, Ellen C.; Felton, Jamie L.; Duan, Daisy; Cromer, Sara J.; Corcoy, Rosa; Colclough, Kevin; Clark, Amy L.; Bodhini, Dhanasekaran; Benham, Jamie L.; Aiken, Catherine; Merino, Jordi; Tobias, Deirdre K.; Gomez, Maria F.; Mathioudakis, Nestoras (Journal article; Peer reviewed, 2024)
      Background Precision medicine has the potential to improve cardiovascular disease (CVD) risk prediction in individuals with Type 2 diabetes (T2D). Methods We conducted a systematic review and meta-analysis of ...

    • Safety of baricitinib in vaccinated patients with severe and critical COVID-19 sub study of the randomised Bari-SolidAct trial 

      Viermyr, Hans-Kittil; Tonby, Kristian; Ponzi, Erica; Trouillet-Assant, Sophie; Poissy, Julien; Arribas, José R.; Dyon-Tafani, Virginie; Bouscambert-Duchamp, Maude; Assoumou, Lambert; Halvorsen, Bente; Tekin, Nuriye Basdag; Diallo, Alpha; de Gastines, Lucie; Munthe, Ludvig A; Murphy, Sarah Louise Mikalsen; Ueland, Thor; Michelsen, Annika Elisabet; Lund-Johansen, Fridtjof; Aukrust, Pål; Mootien, Joy; Dervieux, Benjamin; Zerbib, Yoann; Richard, Jean-Christophe; Prével, Renaud; Malvy, Denis; Timsit, Jean-François; Peiffer-Smadja, Nathan; Roux, Damien; Piroth, Lionel; Ait-Oufella, Hafid; Vieira, Cesar; Dalgard, Olav; Heggelund, Lars; Müller, Karl Erik; Møller, Jannicke Horjen; Kildal, Anders Benjamin; Skogen, Vegard; Aballi, Saad; Øgaard, Jonas Daniel Sjøberg; Dyrhol-Riise, Anne Margarita; Tveita, Anders; Alirezaylavasani, Amin; Costagliola, Dominique; Yazdanpanah, Yazdan; Olsen, Inge Christoffer; Dahl, Tuva Børresdatter; Kared, Hassen; Holten, Aleksander Rygh; Trøseid, Marius (Journal article; Peer reviewed, 2025)
      Background The Bari-SolidAct randomized controlled trial compared baricitinib with placebo in patients with severe COVID-19. A post hoc analysis revealed a higher incidence of serious adverse events (SAEs) among ...

    • The age-dependent regulation of pancreatic islet landscape is fueled by a HNF1a-immune signaling loop 

      Mathisen, Andreas Frøslev; Legøy, Thomas Aga; Larsen, Ulrik; Unger, Lucas; Abadpour, Shadab; Paulo, Joao A.; Scholz, Hanne; Ghila, Luiza Mihaela; Chera, Simona (Journal article; Peer reviewed, 2024)
      Animal longevity is a function of global vital organ functionality and, consequently, a complex polygenic trait. Yet, monogenic regulators controlling overall or organ-specific ageing exist, owing their conservation to ...

    • Krill oil supplementation in vivo promotes increased fuel metabolism and protein synthesis in cultured human skeletal muscle cells 

      Katare, Parmeshwar Bajirao; Dalmao-Fernandez, Andrea; Mengeste, Abel Mulu; Navabakbar, Farnaz; Hamarsland, Håvard; Ellefsen, Stian; Berge, Rolf Kristian; Bakke, Hege Gilbø; Nyman, Tuula Anneli; Kase, Eili Tranheim; Rustan, Arild Christian; Thoresen, G. Hege (Journal article; Peer reviewed, 2024)
      Introduction: Krill oil is a dietary supplement derived from Antarctic krill; a small crustacean found in the ocean. Krill oil is a rich source of omega-3 fatty acids, specifically eicosapentaenoic acid and docosahexaenoic ...

    • Case report: Ketogenic diet alleviated anxiety and depression associated with insulin-dependent diabetes management 

      Winje, Eirin; Lake, Ian; Dankel, Simon N (Journal article; Peer reviewed, 2024)
      Differentiating between an irrational versus a rational fear of hypoglycemia has treatment implications and presents significant challenge for clinicians facing patients with type 1 diabetes, illustrated in this case. A ...

    • Down syndrome and associated atrioventricular septal defects in a nationwide Norwegian cohort: Prevalence, time trends, and outcomes 

      Nordklev, Cecilie Bryn; Gjesdal, Ola; Gunnes, Nina; Holmstrøm, Henrik; Morken, Nils-Halvdan; Vangen, Siri; Sitras, Vasilis (Journal article; Peer reviewed, 2024)
      Introduction The prevalence of Down syndrome (DS) is approximately 1 per 1000 births and is influenced by increasing maternal age over the last few decades. DS is strongly associated with congenital heart defects (CHDs), ...

    • Rare copy number variation in autoimmune Addison’s disease 

      Artaza, Haydee; Eriksson, Daniel; Lavrichenko, Ksenia; Aranda-Guillén, Maribel; Bratland, Eirik; Vaudel, Marc; Knappskog, Per Morten; Husebye, Eystein Sverre; Bensing, Sophie; Wolff, Anette Susanne Bøe; Kämpe, Olle; Røyrvik, Ellen Christine; Johansson, Stefan (Journal article; Peer reviewed, 2024-03-18)
      Autoimmune Addison’s disease (AAD) is a rare but life-threatening endocrine disorder caused by an autoimmune destruction of the adrenal cortex. A previous genome-wide association study (GWAS) has shown that common variants ...

    • Serum concentrations of lipids, ketones and acylcarnitines during the postprandial and fasting state: the Postprandial Metabolism (PoMet) study in healthy young adults 

      Anfinsen, Åslaug Matre; Myklebust, Vilde Haugen; Johannesen, Christina Osland; Christensen, Jacob J.; Laupsa-Borge, Johnny; Dierkes, Jutta; Nygård, Ottar Kjell; McCann, Adrian; Rosendahl-Riise, Hanne; Lysne, Vegard (Journal article; Peer reviewed, 2024)
      To improve the interpretation and utilisation of blood lipids, ketones and acylcarnitine concentrations as biomarkers in clinical assessments, more information is needed on their dynamic alterations in response to dietary ...

    • HLA-DQB1 as a potential prognostic biomarker of hormonal therapy in patients with non-obstructive azoospermia 

      Malcher, Agnieszka; Kamieniczna, Marzena; Rozwadowska, Natalia; Stokowy, Tomasz; Berger, Anna; Jedrzejczak, Piotr; Wolski, Jan Karol; Kurpisz, Maciej (Journal article; Peer reviewed, 2024)
      The gonadotropin treatment of infertile men may improve spermatogenesis and lead to sperm cell production, however, only a small fraction of treated patients positively responds to such therapy. To identify individual ...

    • An ultrasensitive routine LC-MS/MS method for estradiol and estrone in the clinically relevant sub-picomolar range 

      Bertelsen, Bjørn-Erik; Kellmann, Ralf; Viste, Kristin; Bjørnevik, Anne Turid; Eikesdal, Hans Petter; Lønning, Per Eystein; Sagen, Jørn V.; Almås, Bjørg (Journal article; Peer reviewed, 2020)
      Background Current analytical routine methods lack the sensitivity to monitor plasma estrogen levels in breast cancer patients treated with aromatase inhibitors. Such monitoring is warranted for premenopausal patients ...

    • Diagnostics of Exercise-Induced Laryngeal Obstruction Using Machine Learning: A Narrative Review 

      Mæstad, Rune; Kvidaland, Haakon Kristian; Clemm, Hege Synnøve Havstad; Røksund, Ola Drange; Arghandeh, Reza (Journal article; Peer reviewed, 2024-05-11)
      Objective: This paper explores machine learning methods for exercise-induced laryngeal obstruction (EILO) diagnostics. Traditional diagnostic approaches like CLE scoring face subjectivity, limiting precise objective ...

    • Factors that influence recruitment to COVID-19 vaccine trials: a qualitative evidence synthesis 

      Biesty, Linda M.; Meskell, Pauline; Sheehan, Sarah; Dowling, Maura; Glenton, Claire; Shepperd, Sasha; Chan, Xin Hui S.; Cox Brokstad, Rebecca Jane; Devane, Declan; Booth, Andrew; Houghton, Catherine (Journal article; Peer reviewed, 2024-12-19)
      Background: The COVID-19 pandemic marked a unique period characterised by an extraordinary global virus spread. The collective effort to halt the transmission of the virus led to various public health initiatives, including ...