Blar i Department of Clinical Science på dokumenttype "Journal article"

Viser treff 61-80 av 1946

    • Anatomy and evolution of database search engines — a central component of mass spectrometry based proteomic workflows 

      Verheggen, Kenneth; Ræder, Helge; Berven, Frode; Martens, Lennart Martens; Barsnes, Harald; Vaudel, Marc (Peer reviewed; Journal article, 2017-09-13)
      Sequence database search engines are bioinformatics algorithms that identify peptides from tandem mass spectra using a reference protein sequence database. Two decades of development, notably driven by advances in mass ...

    • Ancestrally Duplicated Conserved Noncoding Element Suggests Dual Regulatory Roles of HOTAIR in cis and trans 

      Nepal, Chirag; Taranta, Andrzej; Hadzhiev, Yavor; Pundhir, Sachin; Mydel, Piotr Mateusz; Lenhard, Boris; Müller, Ferenc; Andersen, Jesper B. (Journal article; Peer reviewed, 2020-04)
      HOTAIR was proposed to regulate either HoxD cluster genes in trans or HoxC cluster genes in cis, a mechanism that remains unclear. We have identified a 32-nucleotide conserved noncoding element (CNE) as HOTAIR ancient ...

    • Aneuploidy related transcriptional changes in endometrial cancer link low expression of chromosome 15q genes to poor survival 

      Mauland, Karen Klepsland; Wik, Elisabeth; Høivik, Erling Andre; Kusonmano, Kanthida; Halle, Mari Kyllesø; Berg, Anna; Haugland, Hans Kristian; Øyan, Anne Margrete; Kalland, Karl-Henning; Stefansson, Ingunn Marie; Akslen, Lars A.; Krakstad, Camilla; Trovik, Jone; Werner, Henrica Maria Johanna; Salvesen, Helga Birgitte (Peer reviewed; Journal article, 2017)
      Aneuploidy is a widely studied prognostic marker in endometrial cancer (EC), however, not implemented in clinical decision-making. It lacks validation in large prospective patient cohorts adjusted for currently standard ...

    • Angiopoietin-2 and angiopoietin-like 4 protein provide prognostic information in patients with suspected acute coronary syndrome 

      Aarsetøy, Reidun; Ueland, Thor; Aukrust, Pål; Michelsen, Annika E.; de la Fuente, Ricardo Leon; Pønitz, Volker; Andersen, Trygve Brugger; Grundt, Heidi; Staines, Harry; Nilsen, Dennis W.T. (Journal article; Peer reviewed, 2021)
      Background Plasma levels of angiopoietin-2 (ANGPT2) and angiopoietin-like 4 protein (ANGPTL4) reflect different pathophysiological aspects of cardiovascular disease. We evaluated their association with outcome in a ...

    • Anthropometrics of neonates born to mothers with PCOS with metformin or placebo exposure in utero 

      Nilsen, Guro Ørndal; Simpson, Melanie Rae; Hanem, Liv Guro Engen; Løvvik, Tone Shetelig; Ødegård, Rønnaug Astri; Stokkeland, Live Marie T; Andersen, Marianne; Juliusson, Pétur Benedikt; Vanky, Eszter Ilona (Journal article; Peer reviewed, 2023)
      Introduction: Fetal growth may be affected by both maternal polycystic ovary syndrome (PCOS) and metformin therapy. Here, we explore the effect of intrauterine metformin exposure on birth anthropometrics of infants born ...

    • Anti-HMGB1 auto-Abs influence fatigue in patients with Crohn’s disease 

      Kvivik, Ingeborg; Grimstad, Tore Bjørn; Jonsson, Grete; Kvaløy, Jan T.; Omdal, Roald (Journal article; Peer reviewed, 2021)
      Fatigue is common in all chronic inflammatory and autoimmune diseases. A conceptual model for understanding the biological basis of fatigue describes it as being a part of the sickness behaviour response generated by ...

    • Anti-Interferon Autoantibodies in Autoimmune Polyendocrinopathy Syndrome Type 1 

      Meager, Anthony; Visvalingam, Kumuthini; Peterson, Pärt; Möll, Kaidi; Murumägi, Astrid; Krohn, Kai; Eskelin, Petra; Perheentupa, Jaakko; Husebye, Eystein Sverre; Kadota, Yoshihisa; Willcox, Nick (Peer reviewed; Journal article, 2006-06-13)
      Background The autoimmune regulator (AIRE) gene influences thymic self-tolerance induction. In autoimmune polyendocrinopathy syndrome type 1 (APS1; OMIM 240300), recessive AIRE mutations lead to autoimmunity targetting ...

    • Anti-proliferative activity of the NPM1 interacting natural product avrainvillamide in acute myeloid leukemia 

      Andresen, Vibeke; Erikstein, Bjarte Skoe; Mukherjee, Herschel; Sulen, Andre; Popa, Mihaela Lucia; Sørnes, Steinar; Reikvam, Håkon; Chan, Kok-Ping; Hovland, Randi; McCormack, Emmet; Bruserud, Øystein; Myers, Andrew G.; Gjertsen, Bjørn Tore (Peer reviewed; Journal article, 2016-12-01)
      Mutated nucleophosmin 1 (NPM1) acts as a proto-oncogene and is present in ~30% of patients with acute myeloid leukemia (AML). Here we examined the in vitro and in vivo anti-leukemic activity of the NPM1 and chromosome ...

    • Antibiotic use in children before, during and after hospitalisation 

      Thaulow, Christian Magnus; Blix, Hege Salvesen; Nilsen, Roy Miodini; Eriksen, Beate Horsberg; Wathne, Jannicke Slettli; Berild, Dag; Harthug, Stig (Journal article; Peer reviewed, 2022)
      Purpose: To investigate ambulatory antibiotic use in children during 1 year before and 1 year after in-hospital antibiotic exposure compared to children from the general population that had not received antibiotics ...

    • Antibody levels in a cohort of pregnant women after the 2009 influenza A(H1N1) pandemic: Waning and association with self-reported severity and duration of illness 

      Tunheim, Gro; Laake, Ida; Robertson, Anna Hayman; Waalen, Kristian; Hungnes, Olav; Næss, Lisbeth Meyer; Cox, Rebecca Jane; Mjaaland, Siri; Trogstad, Lill (Peer reviewed; Journal article, 2018-12-09)
      Background: A population‐based pregnancy cohort was established in Norway to study potential effects of exposure to the 2009 influenza pandemic or pandemic vaccination during pregnancy. Objectives: We studied maternal ...

    • Antibody-mediated interferences affecting cardiac troponin assays: recommendations from the IFCC Committee on Clinical Applications of Cardiac Biomarkers 

      Hammarsten, Ola; Warner, Janet V.; Lam, Leo; Kavsak, Peter; Lindahl, Bertil; Aakre, Kristin Moberg; Collinson, Paul; Jaffe, Allan S.; Saenger, Amy K.; Body, Richard; Mills, Nicholas L.; Omland, Torbjørn; Ordonez-Llanos, Jordi; Apple, Fred S. (Journal article; Peer reviewed, 2023)
      The International Federation of Clinical Chemistry Committee on Clinical Applications of Cardiac Biomarkers (IFCC C-CB) provides educational documents to facilitate the interpretation and use of cardiac biomarkers in ...

    • The antihypertensive MTHFR gene polymorphism rs17367504-G is a possible novel protective locus for preeclampsia 

      Thomsen, Liv Cecilie Vestrheim; McCarthy, Nina; Melton, Philip E.; Cadby, Gemma; Austgulen, Rigmor; Nygård, Ottar; Johnson, Matthew P; Brennecke, Shaun P.; Moses, Eric K; Bjørge, Line; Iversen, Ann-Charlotte (Peer reviewed; Journal article, 2016-01)
      Objective: Preeclampsia is a complex heterogeneous disease commonly defined by new-onset hypertension and proteinuria in pregnancy. Women experiencing preeclampsia have increased risk for cardiovascular diseases (CVD) later ...

    • Antimicrobial therapy of community-acquired pneumonia during stewardship efforts and a coronavirus pandemic: an observational study 

      Waagsbø, Bjørn; Tranung, Morten; Damås, Jan Kristian; Heggelund, Lars (Journal article; Peer reviewed, 2022-10-14)
      Background: Community-acquired pneumonia (CAP) is the most frequent infection diagnosis in hospitals. Antimicrobial therapy for CAP is depicted in clinical practice guidelines, but adherence data and effect of antibiotic ...

    • Anxiety and depression in patients aged 80 years and older following aortic valve therapy. A six‑month follow‑up study 

      Eide, Leslie S.P.; Fridlund, Bengt Gotthard Anton; Hufthammer, Karl Ove; Haaverstad, Rune; Packer, Erik; Ranhoff, Anette Hylen; Thompson, David R; Norekvål, Tone Merete (Journal article; Peer reviewed, 2023)
      Background Little is known about mental health following advanced cardiac procedures in the oldest patients. Aims To study changes in anxiety and depression from baseline to one- and six-month follow-up in older ...

    • Aortic root dilatation in hypertensive patients with left ventricular hypertrophy–application of a new multivariate predictive model. The Life Study 

      Lilja-Cyron, Alexander; Bang, Casper N.; Gerdts, Eva; Larstorp, Anne Cecilie Kjeldsen; Kjeldsen, Sverre; Julius, Stevo; Okin, Peter M.; Wachtell, Kristian; Devereux, Richard B. (Journal article, 2022)
      Background: Available nomograms to predict aortic root (AoR) diameter for body surface area have limitations. The purpose of this study was to evaluate the use of a new multivariate predictive model to identify AoR dilatation ...

    • APOBEC3A/B deletion polymorphism and endometrial cancer risk 

      Sofiyeva, Nigar; Krakstad, Camilla; Halle, Mari Kyllesø; O'Mara, Tracy A.; Romundstad, Pål Richard; Hveem, Kristian; Vatten, Lars Johan; Lønning, Per Eystein; Gansmo, Liv Beathe; Knappskog, Stian (Journal article; Peer reviewed, 2022)
      Background A common 30 kb deletion affecting the APOBEC3A and APOBEC3B genes has been linked to increased APOBEC activity and APOBEC-related mutational signatures in human cancers. The role of this deletion as a cancer ...

    • Applications of Machine Learning in Human Microbiome Studies: A Review on Feature Selection, Biomarker Identification, Disease Prediction and Treatment 

      Marcos-Zambrano, Laura Judith; Hadziabdic, Kanita Karaduzovic; Turukalo, Tatjana Loncar; Przymus, Piotr; Trajkovik, Vladimir; Aasmets, Oliver; Berland, Magali; Gruca, Aleksandra; Hasic, Jasminka; Hron, Karel; Klammsteiner, Thomas; Kolev, Mikhail; Lahti, Leo; Lopes, Marta B.; Moreno, Victor; Naskinova, Irina; Org, Elin; Paciencia, Ines; Papoutsoglou, Georgios; Shigdel, Rajesh; Stres, Blaz; Vilne, Baiba; Yousef, Malik; Zdravevski, Eftim; Tsamardinos, Ioannis; Carrillo de Santa Pau, Enrique; Claesson, Marcus J.; Moreno-Indias, Isabel; Truu, Jaak (Journal article; Peer reviewed, 2021)
      The number of microbiome-related studies has notably increased the availability of data on human microbiome composition and function. These studies provide the essential material to deeply explore host-microbiome associations ...

    • Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder 

      de Jong, Simone; Diniz, Mateus Jose Abdalla; Saloma, Andiara; Gadelha, Ary; Santoro, Marcos L.; Ota, Vanessa K.; Noto, Cristiano; Morken, Gunnar; Andreassen, Ole Andreas; Melle, Ingrid; Djurovic, Srdjan; Curtis, Charles; Newhouse, Stephen J.; Patel, Hamel; Hall, Lynsey S.; O`Reilly, Paul F.; Belangero, Sintia I.; Bressan, Rodrigo A.; Breen, Gerome (Peer reviewed; Journal article, 2018-10-08)
      Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the ...

    • Approaching a diagnostic point-of-care test for pediatric tuberculosis through evaluation of immune biomarkers across the clinical disease spectrum 

      Jenum, Synne; Sivakumaran, Dhanasekaran; Lodha, Rakesh; Mukherjee, Aparna; Saini, Deepak Kumar; Singh, Sarman; Singh, Varinder; Medigeshi, Guruprasad; Haks, Marielle C.; Ottenhoff, Tom H.M.; Doherty, Timothy Mark; Kabra, Sushil K.; Ritz, Christian; Grewal, Harleen (Peer reviewed; Journal article, 2016-01-04)
      The World Health Organization (WHO) calls for an accurate, rapid, and simple point-of-care (POC) test for the diagnosis of pediatric tuberculosis (TB) in order to make progress “Towards Zero Deaths”. Whereas the sensitivity ...

    • Arachnoid cysts do not contain cerebrospinal fluid: A comparative chemical analysis of arachnoid cyst fluid and cerebrospinal fluid in adults 

      Berle, Magnus; Wester, Knut; Ulvik, Rune Johan; Kroksveen, Ann Cathrine; Haaland, Øystein; Amiry-Moghaddam, Mahmood; Berven, Frode S. (Peer reviewed; Journal article, 2010-06-10)
      Background Arachnoid cyst (AC) fluid has not previously been compared with cerebrospinal fluid (CSF) from the same patient. ACs are commonly referred to as containing "CSF-like fluid". The objective of this study was to ...