Browsing Department of Clinical Science by Author "Aakre, Kristin Moberg"
Now showing items 1-13 of 13
-
Analytical performance of cardiac troponin assays – Current status and future needs
Aakre, Kristin Moberg; Saeed, Nasir; Wu, Alan H.B.; Kavsak, Peter A. (Journal article; Peer reviewed, 2020)Concurrent with the introduction of cardiac troponin measurements into the diagnostic definition of myocardial infarction (MI), clinicians and laboratory professionals signaled a clear clinical need for improved analytical ... -
Cardiac Troponin Assays With Improved Analytical Quality: A Trade-Off Between Enhanced Diagnostic Performance and Reduced Long-Term Prognostic Value
Tjora, Hilde Lunde; Steiro, Ole-Thomas; Langørgen, Jørund; Bjørneklett, Rune; Nygård, Ottar; Skadberg, Øyvind; Bonarjee, Vernon; Collinson, Paul; Omland, Torbjørn; Vikenes, Kjell; Aakre, Kristin Moberg (Journal article; Peer reviewed, 2020)Background Cardiac troponin (cTn) permits early rule‐out/rule‐in of patients admitted with possible non–ST‐segment–elevation myocardial infarction. In this study, we developed an admission and a 0/1 hour rule‐out/rule‐in ... -
Determinants of interindividual variation in exercise-induced cardiac troponin I levels
Bjørkavoll-Bergseth, Magnus; Erevik, Christine Bjørkvik; Kleiven, Øyunn; Eijsvogels, Thijs M. H.; Skadberg, Øyvind; Frøysa, Vidar; Wiktorski, Tomasz; Auestad, Bjørn; Edvardsen, Thor; Aakre, Kristin Moberg; Ørn, Stein (Journal article; Peer reviewed, 2021)Background: Postexercise cardiac troponin levels show considerable interindividual variations. This study aimed to identify the major determinants of this postexercise variation in cardiac troponin I (cTnI) following 3 ... -
Duration of elevated heart rate Is an important predictor of exercise-induced troponin elevation
Bjørkavoll-Bergseth, Magnus; Kleiven, Øyunn; Auestad, Bjørn Henrik; Eftestøl, Trygve Christian; Oskal, Kay Raymond; Nygård, Martin; Skadberg, Øyvind; Aakre, Kristin Moberg; Melberg, Tor Harald; Gjesdal, Knut; Ørn, Stein (Journal article; Peer reviewed, 2020)Background The precise mechanisms causing cardiac troponin (cTn) increase after exercise remain to be determined. The aim of this study was to investigate the impact of heart rate (HR) on exercise‐induced cTn increase by ... -
Endurance exercise training volume is not associated with progression of coronary artery calcification
Kleiven, Øyunn; Bjørkavoll-Bergseth, Magnus; Omland, Torbjørn; Aakre, Kristin Moberg; Frøysa, Vidar; Erevik, Christine B.; Greve, Ole Jacob; Melberg, Tor Harald; Auestad, Bjørn Henrik; Skadberg, Øyvind; Edvardsen, Thor; Ørn, Stein (Journal article; Peer reviewed, 2020)Background Recent cross‐sectional studies have suggested a dose‐dependent relationship between lifelong exposure to physical activity and the burden of calcified coronary artery disease (CAD). No longitudinal studies have ... -
Handling of hemolyzed serum samples in clinical chemistry laboratories: The Nordic hemolysis project
Gidske, Gro; Aakre, Kristin Moberg; Rustad, Pål; Sandberg, Sverre; Norling, Anna; Pelanti, Jonna; Henriksen, Gitte; Thorsteinsdóttir, Ingunn; Kristensen, Gunn Berit Berge (Peer reviewed; Journal article, 2019)Hemolysis of blood samples is a pre-analytical challenge that often leads to sample rejection in medical laboratories [1]. Hemolysis occurs when blood cells break down and the intracellular contents leak into the surrounding ... -
High-Sensitivity Cardiac Troponin I and T Response Following Strenuous Activity is Attenuated by Smokeless Tobacco: NEEDED (North Sea Race Endurance Exercise Study) 2014
Skranes, Julia Brox; Kleiven, Øyunn; Aakre, Kristin Moberg; Skadberg, Øyvind; Melberg, Tor Harald; Omland, Torbjørn; Ørn, Stein (Journal article; Peer reviewed, 2020)Background Use of snus, a smokeless tobacco product, is increasing in Scandinavia. Strenuous physical activity is associated with an acute increase in high‐sensitivity cardiac troponin (swhs‐cTn) concentrations. Current ... -
Impact of different preanalytical conditions on results of lupus anticoagulant tests
Kristoffersen, Ann-Helen; Jansrud, Ida; Vannes, Solveig; Åsberg, Arne; Aakre, Kristin Moberg (Peer reviewed; Journal article, 2019)Introduction: The currently recommended preanalytical conditions for lupus anticoagulant (LA) analysis require analyzing samples in fresh or freshly frozen platelet‐poor plasma. The aim of this study was to evaluate whether ... -
Occult obstructive coronary artery disease is associated with prolonged cardiac troponin elevation following strenuous exercise
Kleiven, Øyunn; Omland, Torbjørn; Skadberg, Øyvind; Melberg, Tor Harald; Bjørkavoll-Bergseth, Magnus; Auestad, Bjørn Henrik; Bergseth, Rolf; Greve, Ole Jacob; Aakre, Kristin Moberg; Ørn, Stein (Peer reviewed; Journal article, 2019)Background: Sudden cardiac death among middle-aged recreational athletes is predominantly due to myocardial ischaemia. This study examined whether measuring cardiac troponin I and T (cTnI and cTnT) after strenuous exercise ... -
Physical activity, exercise and cardiac troponins: Clinical implications
Aakre, Kristin Moberg; Omland, Torbjørn (Peer reviewed; Journal article, 2019)Cardiac troponins constitute essential components of the cardiac contractile apparatus and are released into the bloodstream following cardiomyocyte injury. Because of their cardiac specificity, cardiac troponin I or T are ... -
Race duration and blood pressure are major predictors of exercise-induced cardiac troponin elevation
Kleiven, Øyunn; Omland, Torbjørn; Skadberg, Øyvind; Melberg, Tor Harald; Bjørkavoll-Bergseth, Magnus; Auestad, Bjørn Henrik; Bergseth, Rolf; Greve, Ole Jacob; Aakre, Kristin Moberg; Ørn, Stein (Peer reviewed; Journal article, 2019)Background: The underlying mechanisms of the exercise-induced increase in cardiac troponins (cTn) are poorly understood. The aim of this study was to identify independent determinants of exercise-induced cTn increase in a ... -
Regular consumption of cod liver oil is associated with reduced basal and exercise-induced C-reactive protein levels; a prospective observational trial: A NEEDED (The North Sea Race Endurance Exercise Study) 2014 sub-study
Hansen, Mette Wærstad; Ørn, Stein; Erevik, Christine B.; Bjørkavoll-Bergseth, Magnus Friestad; Skadberg, Øyvind; Melberg, Tor Harald; Aakre, Kristin Moberg; Kleiven, Øyunn (Journal article; Peer reviewed, 2021)Background Dietary supplement use among recreational athletes is common, with the intention of reducing inflammation and improving recovery. We aimed to describe the relationship between omega-3 fatty acid supplement use ... -
Systemic Cardiac Troponin T Associated With Incident Atrial Fibrillation Among Patients With Suspected Stable Angina Pectoris
Vavik, Vegard; Pedersen, Eva Ringdal; Svingen, Gard Frodahl Tveitevåg; Solheim, Eivind; Aakre, Kristin Moberg; Tell, Grethe S.; Nygård, Ottar; Vikenes, Kjell (Journal article; Peer reviewed, 2020)Higher concentrations of cardiac troponin T are associated with coronary artery disease (CAD) and adverse cardiovascular prognosis. The relation with incident atrial fibrillation (AF) is less explored. We studied this ...