Blar i Department of Clinical Science på forfatter "Kalland, Karl Henning"

Viser treff 1-5 av 5

    • GM-CSF, Flt3-L and IL-4 affect viability and function of conventional dendritic cell types 1 and 2 

      Lellahi, Seyed Mohammad; Azeem, Waqas; Hua, Yaping; Gabriel, Benjamin; Rye, Kristin Paulsen; Reikvam, Håkon; Kalland, Karl Henning (Journal article; Peer reviewed, 2023-01-12)
      Conventional type 1 dendritic cells (cDC1) and conventional type 2 dendritic cells (cDC2) have attracted increasing attention as alternatives to monocyte-derived dendritic cells (moDCs) in cancer immunotherapy. Use of cDCs ...

    • Liquid Biopsies in Solid Cancers: Implementation in a Nordic Healthcare System 

      Nordgård, Oddmund; Forthun, Rakel Brendsdal; Lapin, Morten; Grønberg, Bjørn Henning; Kalland, Karl Henning; Kopperud, Reidun Kristin; Thomsen, Liv Cecilie Vestrheim; Tjensvoll, Kjersti; Gilje, Bjørnar; Gjertsen, Bjørn Tore; Hovland, Randi (Journal article; Peer reviewed, 2021)
      Liquid biopsies have emerged as a potential new diagnostic tool, providing detailed information relevant for characterization and treatment of solid cancers. We here present an overview of current evidence supporting the ...

    • Novel STAT3 Inhibitors Targeting STAT3 Dimerization by Binding to the STAT3 SH2 Domain 

      Hua, Yaping; Yuan, Xing; Shen, Yun-Heng; Wang, Jinxin; Azeem, Waqas; Yang, Shuo; Gade, Alexandra; Lellahi, Seyed Mohammad; Øyan, Anne Margrete; Ke, Xisong; Zhang, Wei-Dong; Kalland, Karl Henning (Journal article; Peer reviewed, 2022)
      Our drug discovery model has identified two novel STAT3 SH2 domain inhibitors 323–1 and 323–2 (delavatine A stereoisomers) in a series of experiments. In silico computational modeling, drug affinity responsive target ...

    • A phase I prospective, non-randomized trial of autologous dendritic cell-based cryoimmunotherapy in patients with metastatic castration-resistant prostate cancer 

      Thomsen, Liv Cecilie Vestrheim; Honore, Alfred; Reisæter, Lars Anders Rokne; Almås, Bjarte; Børretzen, Astrid; Helle, Svein Inge; Førde, Kristina; Kristoffersen, Einar Klæboe; Kaada, Silje Katrine Helland; Melve, Guro Kristin; Haslerud, Torjan Magne; Biermann, Martin; Bigalke, Iris; Kvalheim, Gunnar; Azeem, Waqas; Olsen, Jan Roger; Gabriel, Benjamin; Knappskog, Stian; Halvorsen, Ole Johan; Akslen, Lars Andreas; Bahn, Duke; Pantel, Klaus; Riethdorf, Sabine; Ragde, Haakon; Gjertsen, Bjørn Tore; Øyan, Anne Margrete; Kalland, Karl Henning; Beisland, Christian (Journal article; Peer reviewed, 2023)
      Metastatic castration-resistant prostate cancer (mCRPC) is an immunologically cold disease with dismal outcomes. Cryoablation destroys cancer tissue, releases tumor-associated antigens and creates a pro-inflammatory ...

    • Proteasome‐mediated regulation of GATA2 expression and androgen receptor transcription in benign prostate epithelial cells 

      Azeem, Waqas; Olsen, Jan Roger; Hellem, Margrete Reime; Hua, Yaping; Marvyin, Kristo; Ke, Xisong; Øyan, Anne Margrete; Kalland, Karl Henning (Journal article; Peer reviewed, 2022)
      GATA2 has been shown to be an important transcription factor together with androgen receptor (AR) in prostate cancer cells. Less is known about GATA2 in benign prostate epithelial cells. We have investigated if GATA2 ...