Blar i Department of Clinical Science på tidsskrift "BMC Cancer"
Viser treff 1-8 av 8
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Context dependent regulatory patterns of the androgen receptor and androgen receptor target genes
(Peer reviewed; Journal article, 2016-07-04)Background Expression of the androgen receptor (AR) is associated with androgen-dependent proliferation arrest and terminal differentiation of normal prostate epithelial cells. Additionally, activation of the AR is required ... -
Effect of the MDM2 promoter polymorphisms SNP309T>G and SNP285G>C on the risk of ovarian cancer in BRCA1 mutation carriers
(Peer reviewed; Journal article, 2012-10-05)Background: While BRCA mutation carriers possess a 20-40% lifetime risk of developing ovarian cancer, knowledge about genetic modifying factors influencing the phenotypic expression remains obscure. We explored the ... -
Importance of endocrine treatment adherence and persistence in breast cancer survivorship: a systematic review
(Journal article; Peer reviewed, 2023)Purpose Adjuvant endocrine treatment is essential for treating luminal subtypes of breast cancer, which constitute 75% of all breast malignancies. However, the detrimental side effects of treatment make it difficult for ... -
MDM2 promoter polymorphism del1518 (rs3730485) and its impact on endometrial and ovarian cancer risk
(Peer reviewed; Journal article, 2017-02-03)Background: The del1518 (rs3730485) polymorphism is an in/del variant in the MDM2 promoter P1. The variant is in complete linkage disequilibrium with MDM2 SNP309 (rs2279744) and has previously been found associated with ... -
Predictors of adherence and the role of primary non-adherence in antihormonal treatment of breast cancer
(Journal article; Peer reviewed, 2022-12-02)Background: Antihormonal treatment for hormone receptor (HR) positive breast cancer has highly beneficial effects on both recurrence rates and survival. We investigate adherence and persistence in this group of ... -
Prognostic value of metabolic response in breast cancer patients receiving neoadjuvant chemotherapy
(Peer reviewed; Journal article, 2012-01-25)Background: Today’s clinical diagnostic tools are insufficient for giving accurate prognosis to breast cancer patients. The aim of our study was to examine the tumor metabolic changes in patients with locally advanced ... -
Quantitative DNA methylation analyses reveal stage dependent DNA methylation and association to clinico-pathological factors in breast tumors
(Peer reviewed; Journal article, 2013-10-05)Background: Aberrant DNA methylation of regulatory genes has frequently been found in human breast cancers and correlated to clinical outcome. In the present study we investigate stage specific changes in the DNA methylation ... -
Steroid receptor coactivators, HER-2 and HER-3 expression is stimulated by tamoxifen treatment in DMBA-induced breast cancer
(Peer reviewed; Journal article, 2012-06-15)Background: Steroid receptor coactivators (SRCs) may modulate estrogen receptor (ER) activity and the response to endocrine treatment in breast cancer, in part through interaction with growth factor receptor signaling ...