Blar i Department of Clinical Science på tidsskrift "BMC Genomics"

Viser treff 1-7 av 7

    • Comprehensive characterization of copy number variation (CNV) called from array, long- and short-read data 

      Lavrichenko, Ksenia; Johansson, Stefan; Jonassen, Inge (Journal article; Peer reviewed, 2021)
      Background SNP arrays, short- and long-read genome sequencing are genome-wide high-throughput technologies that may be used to assay copy number variants (CNVs) in a personal genome. Each of these technologies comes with ...

    • Exploring protocol bias in airway microbiome studies: one versus two PCR steps and 16S rRNA gene region V3 V4 versus V4 

      Drengenes, Christine; Eagan, Tomas Mikal; Haaland, Ingvild; Wiker, Harald G; Nielsen, Rune (Journal article; Peer reviewed, 2021)
      Background Studies on the airway microbiome have been performed using a wide range of laboratory protocols for high-throughput sequencing of the bacterial 16S ribosomal RNA (16S rRNA) gene. We sought to determine the ...

    • Genome wide response to dietary tetradecylthioacetic acid supplementation in the heart of Atlantic Salmon (Salmo salar L.) 

      Grammes, Fabian; Rørvik, Kjell-Arne; Thomassen, Magny S.; Berge, Rolf Kristian; Takle, Harald Rune (Peer reviewed; Journal article, 2012-05-11)
      Background: Under-dimensioned hearts causing functional problems are associated with higher mortality rates in intensive Atlantic salmon aquaculture. Previous studies have indicated that tetradecylthioacetic acid (TTA) ...

    • High accuracy mass spectrometry analysis as a tool to verify and improve gene annotation using Mycobacterium tuberculosis as an example 

      De Souza, Gustavo A.; Målen, Hiwa; Søfteland, Tina; Sælensminde, Gisle; Prasad, Swati; Jonassen, Inge; Wiker, Harald G. (Peer reviewed; Journal article, 2008-07-02)
      Background: While the genomic annotations of diverse lineages of the Mycobacterium tuberculosis complex are available, divergences between gene prediction methods are still a challenge for unbiased protein dataset generation. ...

    • MicroRNAs enrichment in GWAS of complex human phenotypes 

      Goulart, Luiz Fernando De Souza; Bettella, Franscesco; Sønderby, Ida Elken; Schork, AJ; Thompson, Kurt Wesley; Mattingsdal, Morten; Steen, Vidar Martin; Zuber, Verena; Wang, Yunpeng; Dale, Anders; Andreassen, Ole Andreas; Djurovic, Srdjan (Peer reviewed; Journal article, 2015-04-16)
      Background: The genotype information carried by Genome-wide association studies (GWAS) seems to have the potential to explain more of the ‘missing heritability’ of complex human phenotypes, given improved statistical ...

    • miR-486-5p expression is regulated by DNA methylation in osteosarcoma 

      Namløs, Heidi Maria; Skårn, Magne Nordang; Ali, Deeqa Ahmed Mohamed; Grad, Iwona; Andresen, Kim; Kresse, Stine Henrichson; Munthe, Else; Serra, Massimo; Scotlandi, Katia; Llombart-Bosch, Antonio; Myklebost, Ola; Lind, Guro Elisabeth; Meza, Leonardo Zepeda (Journal article; Peer reviewed, 2022)
      Background Osteosarcoma is the most common primary malignant tumour of bone occurring in children and young adolescents and is characterised by complex genetic and epigenetic changes. The miRNA miR-486-5p has been shown ...

    • Stage-specific transcriptomic changes in pancreatic α-cells after massive β-cell loss 

      Oropeza, Daniel; Cigliola, Valentina; Romero, Agustín; Chera, Simona; Rodríguez-Seguí, Santiago; Herrera, Pedro L. (Journal article; Peer reviewed, 2021)
      Background Loss of pancreatic insulin-secreting β-cells due to metabolic or autoimmune damage leads to the development of diabetes. The discovery that α-cells can be efficiently reprogrammed into insulin-secreting cells ...