Blar i Department of Clinical Science på tidsskrift "Cancer Medicine"
Viser treff 1-7 av 7
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The added value of multi-state modelling in a randomized controlled trial: The HOVON 102 study re-analyzed
(Journal article; Peer reviewed, 2022)Clofarabine is an active antileukemic drug for subgroups of patients with acute myeloid leukemia (AML). Multi-state models can provide additional insights to supplement the original intention-to-treat analysis of randomized ... -
APOBEC3A/B deletion polymorphism and endometrial cancer risk
(Journal article; Peer reviewed, 2022)Background A common 30 kb deletion affecting the APOBEC3A and APOBEC3B genes has been linked to increased APOBEC activity and APOBEC-related mutational signatures in human cancers. The role of this deletion as a cancer ... -
Are 90% of deaths from cancer caused by metastases?
(Peer reviewed; Journal article, 2019)Numerous publications have stated that metastases are responsible for 90% of cancer deaths, but data underlying this assertion has been lacking. Our objective was to determine what proportions of cancer deaths are caused ... -
Consequences of a high incidence of microsatellite instability and BRAF-mutated tumors: A population-based cohort of metastatic colorectal cancer patients
(Peer reviewed; Journal article, 2019-05-09)Background: Immunotherapy for patients with microsatellite-instable (MSI-H) tumors or BRAF-inhibitors combination treatment for BRAF-mutated (mutBRAF) tumors in metastatic colorectal cancer (mCRC) is promising, but the ... -
Molecular and phenotypic characteristics influencing the degree of cytoreduction in high-grade serous ovarian carcinomas
(Journal article; Peer reviewed, 2023)Background: High-grade serous ovarian carcinoma (HGSOC) is the deadliest ovarian cancer subtype, and survival relates to initial cytoreductive surgical treatment. The existing tools for surgical outcome prediction remain ... -
Prognostic significance of S100A4 expression in stage II and III colorectal cancer: results from a population-based series and a randomized phase III study on adjuvant chemotherapy
(Peer reviewed; Journal article, 2016-08)Current clinical algorithms are unable to precisely predict which colorectal cancer patients would benefit from adjuvant chemotherapy, and there is a need for novel biomarkers to improve the selection of patients. The ... -
β2-adrenergic receptor expression in patients receiving bevacizumab therapy for metastatic melanoma
(Journal article; Peer reviewed, 2023)Background Vascular endothelial growth factor (VEGF) was initially known as vascular permeability factor and identified as a driver of tumour angiogenesis. Recently, its role in supporting an immunosuppressive tumour ...