Blar i Department of Clinical Science på tidsskrift "Cell reports"
Viser treff 1-5 av 5
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Autocrine activation of MAPK signaling mediates intrinsic tolerance to androgen deprivation in LY6D prostate cancer cells
(Journal article; Peer reviewed, 2023)The emergence of castration-resistant prostate cancer remains an area of unmet clinical need. We recently identified a subpopulation of normal prostate progenitor cells, characterized by an intrinsic resistance to androgen ... -
Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through the cAMP/PKA pathway
(Journal article; Peer reviewed, 2022)Heterozygous loss-of-function (LoF) mutations in SETD1A, which encodes a subunit of histone H3 lysine 4 methyltransferase, cause a neurodevelopmental syndrome and increase the risk for schizophrenia. Using CRISPR-Cas9, we ... -
OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation
(Journal article; Peer reviewed, 2020)Oxidation resistance gene 1 (OXR1) protects cells against oxidative stress. We find that male mice with brain-specific isoform A knockout (Oxr1A−/−) develop fatty liver. RNA sequencing of male Oxr1A−/− liver indicates ... -
PARP-inhibition reprograms macrophages toward an anti-tumor phenotype
(Journal article; Peer reviewed, 2022)Poly(ADP)ribosylation inhibitors (PARPis) are toxic to cancer cells with homologous recombination (HR) deficiency but not to HR-proficient cells in the tumor microenvironment (TME), including tumor-associated macrophages ... -
Prognostic impact of vitamin B6 metabolism in lung cancer
(Peer reviewed; Journal article, 2012-08-30)Patients with non-small cell lung cancer (NSCLC) are routinely treated with cytotoxic agents such as cisplatin. Through a genome-wide siRNA-based screen, we identified vitamin B6 metabolism as a central regulator of cisplatin ...