Blar i Department of Clinical Science på tidsskrift "Clinical Epigenetics"
Viser treff 1-4 av 4
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Assessment of tumor suppressor promoter methylation in healthy individuals
(Journal article; Peer reviewed, 2020-08)Background The number of tumor suppressor genes for which germline mutations have been linked to cancer risk is steadily increasing. However, while recent reports have linked constitutional normal tissue promoter methylation ... -
The combination of valproic acid, all-trans retinoic acid and low-dose cytarabine as disease-stabilizing treatment in acute myeloid leukemia
(Peer reviewed; Journal article, 2013-08-01)Background: A large proportion of patients with acute myeloid leukemia (AML) are not fit for intensive and potentially curative therapy due to advanced age or comorbidity. Previous studies have demonstrated that a subset ... -
Fathers’ preconception smoking and offspring DNA methylation
(Journal article; Peer reviewed, 2023)Background Experimental studies suggest that exposures may impact respiratory health across generations via epigenetic changes transmitted specifically through male germ cells. Studies in humans are, however, limited. ... -
Histone deacetylase inhibition in the treatment of acute myeloid leukemia: the effects of valproic acid on leukemic cells, and the clinical and experimental evidence for combining valproic acid with other antileukemic agents
(Peer reviewed; Journal article, 2013-07-30)Several new therapeutic strategies are now considered for acute myeloid leukemia (AML) patients unfit for intensive chemotherapy, including modulation of protein lysine acetylation through inhibition of histone deacetylases ...