Blar i Department of Clinical Science på tidsskrift "European Journal of Heart Failure"

Viser treff 1-10 av 10

    • Additional burden of iron deficiency in heart failure patients beyond the cardio-renal anaemia syndrome: findings from the BIOSTAT-CHF study 

      Alnuwaysir, Ridha I.S.; Grote Beverborg, Niels; Hoes, Martijn F.; Markousis-Mavrogenis, George; Gomez, Karla A.; van der Wal, Haye H.; Cleland, John G.; Dickstein, Kenneth; Lang, Chim C.; Ng, Leong L.; Ponikowski, Piotr; Anker, Stefan D.; van Veldhuisen, Dirk J.; Voors, Adriaan A.; van der Meer, Peter (Journal article; Peer reviewed, 2022)
      Aims Whereas the combination of anaemia and chronic kidney disease (CKD) has been extensively studied in patients with heart failure (HF), the contribution of iron deficiency (ID) to this dysfunctional interplay is unknown. ...

    • Biomarker signature and pathophysiological pathways in patients with chronic heart failure and metabolic syndrome 

      van der Hoef, Camilla C.S.; Boorsma, Eva M.; Emmens, Johanna E.; van Essen, Bart J.; Metra, Marco; Ng, Leong L.; Anker, Stefan D.; Dickstein, Kenneth; Mordi, Ify R.; Dihoum, Adel; Lang, Chim C.; van Veldhuisen, Dirk J.; Lam, Carolyn S.P.; Voors, Adriaan A. (Journal article; Peer reviewed, 2023)
      Aim The comorbidities that collectively define metabolic syndrome are common in patients with heart failure. However, the role of metabolic syndrome in the pathophysiology of heart failure is not well understood. We ...

    • Clinical implications of left atrial changes after optimization of medical therapy in patients with heart failure 

      Inciardi, Riccardo M.; Pagnesi, Matteo; Lombardi, Carlo M.; Anker, Stefan D.; Cleland, John G.; Dickstein, Kenneth; Filippatos, Gerasimos S.; Lang, Chim C.; Ng, Leong L.; Pellicori, Pierpaolo; Ponikowski, Piotr; Samani, Nilesh J.; Zannad, Faiez; van Veldhuisen, Dirk J.; Solomon, Scott D.; Voors, Adriaan A.; Metra, Marco (Journal article; Peer reviewed, 2022)
      Aims Limited data exist regarding the prognostic relevance of changes in left atrial (LA) dimensions in patients with heart failure (HF). We assessed changes in LA dimension and their relation with outcomes after optimization ...

    • Dipeptidyl peptidase 3, a marker of the antagonist pathway of the renin–angiotensin–aldosterone system in patients with heart failure 

      Boorsma, Eva M.; ter Maaten, Jozine M.; Damman, Kevin; van Veldhuisen, Dirk J.; Dickstein, Kenneth; Anker, Stefan D.; Filippatos, Gerasimos; Lang, Chim C.; Metra, Marco; Santos, Karine; Voors, Adriaan A. (Journal article; Peer reviewed, 2021)
      Aims Recently, dipeptidyl peptidase 3 (DPP3) has been discovered as the peptidase responsible for cleavage of angiotensin (1–7) [Ang (1–7)]. Ang (1–7) is part of the angiotensin-converting enzyme–Ang (1–7)–Mas pathway ...

    • Distinct pathophysiological pathways in women and men with heart failure 

      Ravera, Alice; Santema, Bernadet T.; de Boer, Rudolf A.; Anker, Stefan D.; Samani, Nilesh J.; Lang, Chim C.; Ng, Leong; Cleland, John G.F.; Dickstein, Kenneth; Lam, Carolyn S.P.; Van Spall, Harriette G. C.; Filippatos, Gerasimos; van Veldhuisen, Dirk J.; Metra, Marco; Voors, Adriaan A.; Sama, Iziah E. (Journal article; Peer reviewed, 2022)
      Aims: Clinical differences between women and men have been described in heart failure (HF). However, less is known about the underlying pathophysiological mechanisms. In this study, we compared multiple circulating biomarkers ...

    • Effects of sildenafil on symptoms and exercise capacity for heart failure with reduced ejection fraction and pulmonary hypertension (the SilHF study): a randomized placebo-controlled multicentre trial 

      Cooper, Trond Johan; Cleland, John G.F.; Guazzi, Marco; Pellicori, Pierpaolo; Ben Gal, Tuvia; Amir, Offer; Al-Mohammad, Abdallah; Clark, Andrew L.; McConnachie, Alex; Steine, Kjetil; Dickstein, Kenneth (Journal article; Peer reviewed, 2022)
      Aims: Pulmonary hypertension (PHT) may complicate heart failure with reduced ejection fraction (HFrEF) and is associated with a substantial symptom burden and poor prognosis. Sildenafil, a phosphodiesterase-5 (PDE-5) ...

    • Impact of mitral regurgitation in patients with worsening heart failure: insights from BIOSTAT-CHF 

      Pagnesi, Matteo; Adamo, Marianna; Sama, Iziah E.; Anker, Stefan D.; Cleland, John G.; Dickstein, Kenneth; Filippatos, Gerasimos S.; Lang, Chim C.; Ng, Leong L.; Ponikowski, Piotr; Ravera, Alice; Samani, Nilesh J.; Zannad, Faiez; van Veldhuisen, Dirk J.; Voors, Adriaan A.; Metra, Marco (Journal article; Peer reviewed, 2021)
      Aims Few data regarding the prevalence and prognostic impact of mitral regurgitation (MR) in patients with worsening chronic or new-onset acute heart failure (HF) are available. We investigated the role of MR in the BIOlogy ...

    • Machine learning based on biomarker profiles identifies distinct subgroups of heart failure with preserved ejection fraction 

      Woolley, Rebecca J.; Ceelen, Daan; Ouwerkerk, Wouter; Tromp, Jasper; Figarska, Sylwia M.; Anker, Stefan D.; Dickstein, Kenneth; Filippatos, Gerasimos; Zannad, Faiez; Marco, Metra; Ng, Leong L.; Samani, Nilesh J.; van Veldhuisen, Dirk J; Lang, Chim C.; Lam, Carolyn S.P.; Voors, Adriaan A. (Journal article; Peer reviewed, 2021)
      Aims The lack of effective therapies for patients with heart failure with preserved ejection fraction (HFpEF) is often ascribed to the heterogeneity of patients with HFpEF. We aimed to identify distinct pathophysiologic ...

    • Pathophysiological pathways related to high plasma growth differentiation factor 15 concentrations in patients with heart failure 

      Ceelen, Daan; Voors, Adriaan A.; Tromp, Jasper; van Veldhuisen, Dirk J.; Dickstein, Kenneth; de Boer, Rudolf A.; Lang, Chim C.; Anker, Stefan D.; Ng, Leong L.; Metra, Marco; Ponikowski, Piotr; Figarska, Sylwia M. (Journal article; Peer reviewed, 2022)
      Aims Elevated concentrations of growth differentiation factor 15 (GDF-15) in patients with heart failure (HF) have been consistently associated with worse clinical outcomes, but what disease mechanisms high GDF-15 ...

    • Quality of life in men and women with heart failure: association with outcome, and comparison between the Kansas City Cardiomyopathy Questionnaire and the EuroQol 5 dimensions questionnaire 

      Ravera, Alice; Santema, Bernadet T.; Sama, Iziah E.; Meyer, Sven; Lombardi, Carlo; Carubelli, Valentina; Ferreira, João Pedro; Lang, Chim C.; Dickstein, Kenneth; Anker, Stefan D.; Samani, Nilesh J.; Zannad, Faiez; van Veldhuisen, Dirk J.; Teerlink, John R.; Metra, Marco; Voors, Adriaan A. (Journal article; Peer reviewed, 2021)
      Aims We sought to analyse quality of life (QoL) measures derived from two questionnaires widely used in clinical trials, the Kansas City Cardiomyopathy Questionnaire (KCCQ) and the EuroQoL 5 dimensions (EQ-5D), and to ...